Indium tin oxide exposure poses a potential health risk, but the exposure assessment in occupational setting remains incomplete and continues to be a significant challenge To this end, we investigated the association of work type, airborne indium concentration, respirable fraction of total indium, and cumulative indium exposure index CEI with the levels of plasma indium P-In and urinary indium U-In among 302 indium tin oxide target manufacturing and recycling workers in Taiwan We observed that recycling-crushing produced the highest concentrations of total indium area 20848 μg/m3; personal 34945 μg/m3 and respirable indium area 5334 μg/m3; personal 7420 μg/m3 Powdering produced the highest respirable fraction of total indium area 586; personal 815, where the workers had the highest levels of P-In geometric mean 20 μg/L and U-In 10 μg/g creatinine After adjusting for the confounder, the CEIs of powdering βPR = 078; βPR = 044, bonding βPT = 061; βPT = 037, and processing workers βPT = 043; βPT = 028 showed significant associations with P-In and U-In, validating its utility in monitoring the exposure Also, the respirable fraction of total indium significantly contributed to the increased levels of P-In and U-In among workers The varying levels of relationship noted between indium exposure and the levels of P-In and U-In among workers with different work types suggested that setting the exposure limits among different work types is warrantedThe levels and characteristics of atmospheric metals vary in time and location, can result in various health impacts, which increases the challenge of air quality management We aimed to investigate PM25-bound metals in multiple locations and propose a methodology for comparing metal elements across study regions and prioritizing source contributions through integrated health risk assessments PM25-bound metals were collected in the urban, suburban, rural, and industrial regions of Taiwan between 2016 and 2018 We incorporated the positive matrix factorization PMF with health risk assessments considering estimates of the margin of exposure MOE and excess cancer risk ECR to prioritize sources for control We found that the concentrations of Fe, Zn, V, Cu, and Mn industry-related metals were higher at the industrial site Kaohsiung and Ba, Cr, Ni, Mo, and Co traffic-related metals were higher at the urban site Taipei The rural site Hualian had good air quality, with low PM25 and metal concentrations Most metal concentrations were higher during the cold season for all study sites, except for the rural Ambient concentrations of Mn, Cr, and Pb obtained from all study sites presents a higher health risk of concern In Kaohsiung, south Taiwan, PM25-bound metals from the iron ore and steel factory is suggested as the first target for control based on the calculated health risks MOE 10-6 Overall, we proposed an integrated strategy for initiating the source management prioritization of PM25-bound metals, which can aid an effort for policymakingIn the environment, microalgae are exposed to a multitude of stressors simultaneously, inducing physiological adjustments It is well documented that both phosphorus P limitation and trace metals exposure affect microalgal physiology However, investigations regarding the combination of both P limitation and excess trace metals still deserve attention In the present study, we evaluated the changes in photosynthetic parameters in the green microalga Ankistrodesmus densus acclimated to different P concentrations prior to exposure to Cd Our results indicate that different concentrations of P in the medium were responsible for significant changes in some parameters, especially those related to photoprotection mechanisms Cadmium also altered some of these variables in all P scenarios, and greater damage ie, synergism was observed in the combination P-limited and high Cd, with all the evaluated parameters affected under the adverse scenario Among the parameters analyzed, rapid light curves were the most sensitive to exposure of one or the combination of both stressors Cd and P limitation Based on our data, we suggest that P-limited algae activated photoprotective mechanisms as a response to nutrient limitation, especially at the most limited condition The addition of Cd did not change linearly the parameters related to photoprotection mechanisms under P-limitation, ie, synergism was observed in the intermediate P-limitation combined with Cd, while in the most P-limited, P seems to be the driving force affecting these mechanisms Based on our results, we suggest the use of rapid light curves as a tool to complement the assessment of the impacts of stressors, such as metals, in ecotoxicological studiesThe public around the world is increasingly concerned about male reproductive health The impact of nickel nanoparticles Ni NPs on male reproductive toxicity including sperm production, motility and fertilizing capacity has been confirmed by our previous researches In the current study of Ni NPs-inducing toxicity, the expression profiles of piRNAs and their predicted target genes associated with male infertility, were obtained The results showed that piR-mmu-32362259 was the highest differential expression multiples in both the testis tissues of male mice and GC-1 cells similarly Notably, piR-mmu-32362259 target gene was significantly enriched in the PI3K-AKT signaling pathway  https//wwwselleckchemcom/  All these results suggest that piR-mmu-32362259 may affect the occurrence and development of injury in the mouse spermatogenesis process by regulating the PI3K-AKT signaling pathway In order to verify the result, piR-mmu-32362259 low-expression lentivirus was used to transfect GC-1 cells to establish a stable transfected cell model The effects of piR-mmu-32362259 on the viability, cycle and apoptosis as well as related protein expression levels of GC-1 cells induced by Ni NPs were detected using CCK8, flow cytometry and western blot assay, respectively The results showed that low expression of piR-mmu-32362259 could not only alleviate the decrease of GC-1 cell viability, affect the cell cycle and reduce the apoptosis rate, but also significantly affect the expression levels of key proteins and their downstream molecules of PI3K/AKT/mTOR signaling pathway Collectively, our current results provide a theoretical basis for further exploring the molecular regulatory mechanism of male reproductive toxicity induced by Ni NPs