Flood disasters have appeared more frequently in recent years because of climate change and urbanization, and Integrated Flood Risk Management (IFRM) has emerged as an effective method to reduce damage from these floods. This research studies IFRM methods in three aspects flood risk identification of high-risk areas, flood risk assessment to quantify economic losses, and flood risk management to identify structural measures with the greatest engineering benefits. These methods were applied to Beijing as a case study, and the results showed that the Zuoan-Road area was a high-risk area with economic losses ranging from 0.7 million to 35.9 million euros over different return periods. There are five structural measures in Zuoan-Road area, with engineering benefits ranging from 0.97 to 1.60 over different return periods, and the one with the greatest engineering benefits had a fifty-year return period. The results of this research can be used to support urban flood risk management in Beijing.There is an ongoing paradigm shift; wastewater is often not considered a waste any more, but a source of valuable resources nutrients (N nitrogen, P phosphorus, and K potassium), energy and water. The recovery of phosphorus from municipal wastewater has gained a lot of attention because of limited phosphate rock reserves and associated geopolitics, and pollution of phosphate rock. At the WWTP of Leuven, Aquafin operates a full scale installation to recover phosphorus as struvite from digested sludge. This paper discusses the performance of the struvite plant, pollutants in the struvite, struvite use, and economics.The variation in the speed and intensity of SARS-CoV-2 transmission and severity of the resulting COVID-19 disease are still imperfectly understood. We postulate a dose-response relationship in COVID-19, and that "the dose of virus in the initial inoculum" is an important missing link in understanding several incompletely explained observations in COVID-19 as a factor in transmission dynamics and severity of disease. We hypothesize that (1) Viral dose in inoculum is related to severity of disease, (2) Severity of disease is related to transmission potential, and (3) In certain contexts, chains of severe cases can build up to severe local outbreaks, and large-scale intensive epidemics. Considerable evidence from other infectious diseases substantiates this hypothesis and recent evidence from COVID-19 points in the same direction. We suggest research avenues to validate the hypothesis. If proven, our hypothesis could strengthen the scientific basis for deciding priority containment measures in various contexts in particular the importance of avoiding super-spreading events and the benefits of mass masking.Dental professionals work closely with patients and present an increased risk of person-to-person transmission of SARS-CoV-2. Moreover, the use of ultrasonic scalers, air-water syringes, and slow and high-speed handpieces, which are common in the dental office, generate spatter and aerosol. NF-κB inhibitor The use of preprocedural mouthrinses has been proposed to reduce the viral load in saliva and oropharyngeal tissues, thus decreasing viral load in dental aerosol. Although some mouthrinses demonstrates an antiviral effect, there is limited evidence about the clinical efficacy of any mouthrinse in the reduction of SARS-CoV-2 in the dental aerosol. We hypothesized that mouthrinses may reduce SARS-CoV-2 viral load in the oropharynx and its fluids reducing viral load in dental aerosol. The potential use of mouthrinses is discussed, along with proposal of in vitro and clinical studies, in order to evaluate this hypothesis. If this hypothesis holds true, dental professionals and patients may benefit from the routine use of preprocedural mouthrinses.European Union (EU) and global sustainability policies emphasize the need to replace contentious pesticides with safe, efficient, and cost-effective alternatives to ensure sustainable food production. However, R&D for alternatives to contentious pesticides are lagging behind and need to be broadened. Here, we discuss how RNAi-based technology can contribute to pesticide risk reduction.Kidney transplant is currently the elective treatment of choice for end-stage renal disease. Laparoscopic living donor nephrectomy (LLDN) has substantial advantages over open nephrectomy. Chylous ascites (CA) is a rare surgical complication after the LLDN; there are few reports in the literature. We present a case report of a 58-year-old woman who started CA on the 21st day post operation. The recommended initial therapeutic approach to suspend the fat in the diet and place percutaneous drainage was not enough. It was decided to jointly introduce fasting and total parenteral nutrition with the administration of octreotide, resolving the complication completely in 15 days with no need for the patient to undergo surgery. The conservative management, during the first 4 to 8 weeks after the diagnosis is the best option. Surgery is generally recommended if conservative management fails. The prevalence of CA varied between 0% and 6.2% of LLDNs. In our experience of 87 LLDNs, we only presented 1.15% for this complication. There are 62 cases reported in the international literature. The mean presentation was 14 days after LLDN. All patients underwent conservative treatment, and only 15 patients (24%) went to surgery after the failure of conservative management. It would be highly useful, considering the disparity of the prevalence, if the bibliographic reports detail what hemostatic and sealing techniques are used in an LLDN. In this way it would be possible to identify which factor affects a complication like this one. Immunosuppressive treatment is often interrupted in the first months following kidney transplant failure (KTF) to limit side effects. The aim of this study was to assess the effect of prolonged treatment (PT) of more than 3 months' duration after KTF on HLA sensitization and treatment tolerance. We performed a retrospective observational study involving 119 patients with KTF in 3 French kidney transplant centers between June 2007 and June 2017. Sensitization was defined as the development of HLA donor-specific antibodies (DSA). In the PT group receiving calcineurin inhibitor (CNI) treatment, 30 of 52 patients (57.7%) were sensitized vs 52 of 67 patients (77.6%) who had early cessation of treatment (P= .02). The results were confirmed by multivariate analysis (odds ratio [OR]= 0.39, 95% confidence interval [CI] [0.16; 0.98], P= .04). The development of de novo DSAs after CNI treatment (n= 63/90 [70.0%]) was significantly more frequent than during CNI treatment, (n= 18/52 [34.6%], P= .01). Panel-reactive antibody≥85% was lower in the PT group in multivariate analysis (OR= 0.

EGFR mutation standing within Middle Japanese people using nonsquamou

Description

RAW Paste Data

Recent Pastes