The primary outcome is health seeking behaviour, measured using the Actual Help Seeking Questionnaire, at 6months' follow-up Data collection will be undertaken at baseline T0, post-intervention-up to 3months T1, at 6months T2, 12months T3 and 24months T4 The primary analysis will be conducted on those participants who receive MHFA, a per protocol analysis
 
  The study is the first to evaluate the effect of MHFA in the workplace on employees with direct and indirect experience of the intervention, when compared with usual practice Being also the first to assess, systematically, the social impact of MHFA and investigate its cost-effectiveness adds to the originality of the study The study promises to yield important data, as yet unknown, regarding the effectiveness, cost-effectiveness, implementation issues, and the sustainability of MHFA in the workplace
 
  Clinicaltrialsgov NCT04311203  Registered on 17 March 2020
 Clinicaltrialsgov NCT04311203  Registered on 17 March 2020
  Intra-Aortic Balloon Pumps IABPs can be utilized to provide hemodynamic support in high risk patients awaiting coronary artery bypass grafting CABG There are many indications for IABP and institutional practice patterns regarding the placement of IABPs is variable As a result, the preoperative placement of an IABP in a patient awaiting CABG is not standardized and may vary according to non-clinical factors We hypothesize that the rate of IABP placement varies by day of the week
 
  A retrospective cohort analysis of the Office of Statewide Health Planning and Development database from 2006 to 2010 was performed All patients admitted for CABG were included Patients who died within 24 h of admission and those who had absolute contraindications to IABP placement were excluded The primary outcome was preoperative IABP placement versus non-placement A multivariable logistic regression analysis to identify predictors of IABP placement was performed, adjusting for patient demographics, clinical factors, and system variables
 
  A total of 46,347 patients underwent CABG, of which 7695 1660 had an IABP placed preoperatively On unadjusted analysis, IABP rates were significantly higher on weekends versus weekdays 2083 vs 1570, p lt; 0001 On adjusted analysis, patients awaiting CABG were 130 times more likely to have an IABP placed on weekends than on weekdays OR 130, 95 CI 120-140, p lt; 0001
 
  The odds of preoperative IABP placement prior to CABG is significantly increased on weekends compared to weekdays, even when controlling for clinical factors Further exploration of this phenomenon and its associations are warranted
 The odds of preoperative IABP placement prior to CABG is significantly increased on weekends compared to weekdays, even when controlling for clinical factors Further exploration of this phenomenon and its associations are warranted
  Repeat Chlamydia trachomatis CT infections are common To better understand the characteristics of patients frequently infected with CT at our sexually transmitted infection STI care services, we assessed the differences between patients repeatedly infected with CT and those who repeatedly tested negative
 
  In this cross-sectional analysis of cohort data, we assessed individuals tested for CT at different STI care providers between 2011 and mid-2018 in Southwest Limburg, the Netherlands n = 17,616 Patients with ≥2 repeat CT infections in the study period were categorized as "patients with repeat CT infections" Multivariable logistic regression analyses were performed for the binary outcome measure patients with repeat CT infections versus patients who repeatedly tested negative reference group Additional analyses were performed for only the STI clinic population
 
  Patients aged lt; 25 years OR 183; 95CI138-243, co-infected with HIV OR 207; 95CI 102-422 or co-infected with Neisseria gonorrhoeae NG OR 504; 95CI 333-763 had more repeat CT infections In additional analyses among exclusively STI clinic visitors, patients with urogenital symptoms OR 217; 95CI 141-335, and patients notified for STIs OR 455; 95CI 317-654 had more frequent repeat CT infections
 
  Patients aged lt; 25 years and patients coinfected with HIV or NG had more frequent repeat CT infections, accounting for ~ 20 of the diagnosed CT infections  https//wwwselleckchemcom/products/bexotegrasthtml  These patients are likely at the highest risk for transmitting and acquiring CT Therefore, testing and retesting this group remains important to enhance CT control
 Patients aged less then  25 years and patients coinfected with HIV or NG had more frequent repeat CT infections, accounting for ~ 20 of the diagnosed CT infections These patients are likely at the highest risk for transmitting and acquiring CT Therefore, testing and retesting this group remains important to enhance CT controlBrucella ovis is a non-zoonotic rough Brucella that causes genital lesions, abortions and increased perinatal mortality in sheep and is responsible for important economic losses worldwide Research on virulence factors of B ovis is necessary for deciphering the mechanisms that enable this facultative intracellular pathogen to establish persistent infections and for developing a species-specific vaccine, a need in areas where the cross-protecting ovine smooth B melitensis Rev1 vaccine is banned Although several B ovis virulence factors have been identified, there is little information on its metabolic abilities and their role in virulence Here, we report that deletion of pyruvate phosphate dikinase PpdK, catalyzing the bidirectional conversion pyruvate ⇌ phosphoenolpyruvate in B ovis PA virulent and CO2-dependent impaired growth in vitro In cell infection experiments, although showing an initial survival higher than that of the parental strain, this ppdK mutant was unable to multiply Moreover, when inoculated at high doses in mice, it displayed an initial spleen colonization higher than that of the parental strain followed by a marked comparative decrease, an unusual pattern of attenuation in mice A homologous mutant was also obtained in a B ovis PA CO2-independent construct previously proposed for developing B ovis vaccines to solve the problem that CO2-dependence represents for large scale production This CO2-independent ppdK mutant reproduced the growth defect in vitro and the multiplication/clearance pattern in mouse spleens, and is thus an interesting vaccine candidate for the immunoprophylaxis of B ovis ovine brucellosis