Community water fluoridation CWF has been a public health measure against tooth decay since 1945 Strong evidence supports the use of CWF in reduction in caries risk in the pediatric population, and numerous studies also show benefit in adults CWF remains an important contributor to oral health despite the availability and widespread use of other fluoride-containing dental products The efficacy, safety, and optimal use of CWF will be discussedObjective Our main purpose is to explore the effect and mechanism of Dexmedetomidine DEX in diabetic nephropathy fibrosis Methods Diabetic model was established by intraperitoneal injection of streptozotocin STZ treated CD-1 mice and high glucose cultured human dermal microvascular endothelial cells HMVECs Immunofluorescence was used to detect renal endothelial-mesenchymal transition EndMT; Hematoxylin and Eosin HE staining and Masson's Trichrome Staining MTS was used to analyze renal fibrosis; CCK-8 was used to evaluate cell viability; Reverse transcription-quantitative polymerase chain reaction RT-qPCR was used to assess the expression of miR-101-3p; Western blots were utilized to judge the protein expression levels of EndMT, extracellular matrix and TGF-β1/Smad3 signal pathway Results In this study, we first found that the protective effect of DEX on DN was related to EndMT DEX alleviated kidney fibrosis by inhibiting EndMT in diabetic CD-1 mice DEX could also inhibit high glucose-induced HMVECs EndMT Then, we confirmed that miR-101-3p was the regulatory target of DEX The expression of miR-101-3p was decreased in diabetic CD-1 mice and high glucose-induced HMVECs After DEX treatment, the miR-101-3p increased, and the inhibition of miR-101-3p could counteract the protective effect of DEX and aggravate the EndMT Finally, we found that the TGF- β1/Smad3 signal pathway was involved in the protective effect of DEX on DN DEX inhibited the activation of TGF-β1/Smad3 signal pathway On the contrary, inhibiting miR-101-3p promoted the expression of TGF-β1/Smad3 Conclusion DEX protects kidney fibrosis in diabetic mice by targeting miR-101-3p-mediated EndMTTranscatheter aortic valve implantation TAVI has become a high-volume procedure with increasing demands on hospital resources Local anaesthesia with sedation supervised by an anaesthesiology team is the current standard of care We aimed to describe our experience with a simplified, nurse-led sedation NLS protocol This study enrolled 128 consecutive patients who underwent transfemoral TAVI with self-expandable Evolut R prosthesis between November 2019 and April 2021 Operators selected 50 of patients for NLS based on the clinical expectation of lower risk of procedural difficulties Nurse-led sedation protocol demanded only mild to moderate levels of sedation The clinical outcomes were determined from the local TAVI registry and the national mortality database Baseline patient characteristics were similar in the NLS n = 64 and anaesthesiologist-led sedation ALS n = 64 groups except higher prevalence of diabetes mellitus 484 vs 313, P = 0035 and peripheral vascular disease 203 vs 78, P = 0036 in the ALS group There was a trend for the larger prostheses used in the ALS group P = 0058 The procedural results did not differ, and coronary care team backup was rarely needed in the NLS group 6 of patients The in-hospital outcomes were identical from both clinical and echocardiography perspectives, and 30-day mortality was low in both groups 15 For the NLS group, preparation in the catheterization laboratory was quicker by 64 min P = 001, and intensive care unit stay was shorter 203 vs 348 days, P = 0001 In conclusion, the NLS for the selected transfemoral TAVI population seems safeTranscatheter aortic valve implantation TAVI varies considerably in terms of the procedural approach taken and the hospital length of stay LoS; both directly affect the cost of care Our coronary and standard cardiology unit aimed to simplify TAVI and thus shorten the LoS while maintaining safety A shorter LoS would also reduce the burden on hospital resources and free up beds for other patients Data on 214 consecutive patients undergoing TAVI at a single centre between April 2018 and March 2021 were retrospectively collected A simplified protocol was implemented in January 2020; patients were stratified by whether they underwent TAVI before or after simplification All procedural phases were simplified For cost comparison purposes, the LoS was defined as the number of hospitalization days from admission to discharge The total hospitalization cost was the sum of the direct and indirect including reallocated overhead costs The LoS fell significantly by 36 after TAVI simplification The times in the coronary care unit CCU and standard cardiac unit SCU also fell significantly by 33 and 37 respectively Patients in the simplified TAVI group were discharged, on average, 6 days after admission The CCU costs decreased by 31 and the SCU costs by 39 Transcatheter aortic valve implantation simplification did not compromise safety Indeed, patients who underwent the simplified procedure seemed to develop fewer complications, especially bleeding Transcatheter aortic valve implantation simplification significantly reduced the LoS and other costs without compromising patient safetyBackground Time is brain This paradigm is forcing the development of strategies with potential to shorten the time from symptom onset to recanalization One of these strategies is to transport select patients with acute ischaemic stroke directly to an angio-suite equipped with flat-detector computed tomography FD-CT to exclude intracranial haemorrhage, followed directly by invasive angiography and mechanical thrombectomy if large-vessel occlusion LVO is confirmed Aim To present existing published data about the direct transfer DT of stroke patients to angio-suites and to describe our initial experience with this stroke pathway Methods We performed a systematic PubMed search of trials that described DT of stroke patients to angio-suites and summarized the results of these trials In January 2020, we implemented a new algorithm for acute ischaemic stroke care in our stroke centre Select patients suitable for DT National Institute of Health Stroke Scale score ≥10, time from symptom onset to door 10, sduce the time from patient arrival in the hospital to groin puncture This reduction in the ischaemic time translates into better clinical outcomes However, more data are needed to confirm these resultsMany scoring systems for predicting the outcomes of patients with acute coronary syndrome ACS have been proposed In some populations, a significant reduction in length of hospital stay may be achieved without compromising patient prognoses However, the use of such scoring systems in clinical practice is limited The aim of this study was to propose a universal list of predictors that can identify low-risk ACS patients who may be eligible for an earlier hospital discharge without increased short-term risk for major adverse cardiac events A cohort of 1420 patients diagnosed with ACS were enrolled into a single-centre registry between October 2018 and December 2020 Clinical, laboratory, echocardiographic, and angiographic measurements were taken for each patient and entered into the study database Using retrospective univariant analyses of patients treated with percutaneous coronary intervention PCI n = 932, we compared each predictor to 30-day mortality rate using the Czech national registry of dead people Eleven predictors correlate significantly with 30-day survival age 110 g/L while hospitalized, successful PCI procedures, no residual stenosis over 90, Thrombolysis in Myocardial Infarction 3 flow after PCI, no left main stem disease, and no triple-vessel coronary artery disease In all, presence of all predictors applies to 328 patients 352 of the cohort, who maintained a 100 survival rate at 30 days A combination of clinical, echocardiographic, and angiographic findings provides valuable information for predicting the outcomes of patients with all types of ACS We created a simple, useful tool for selecting low-risk patients eligible for early dischargeManaging patients with acute coronary syndrome ACS in an ageing population with comorbidities is clinically and economically challenging Well-conducted unselected registries are essential for providing information on real-day clinical practice The aim was to create a long term, very detail-controlled registry of unselected patients admitted with ACS to a high-volume centre in Central Europe Consecutive patients admitted with confirmed ACS were entered into the prospective registry from 1 October 2018 to 30 September 2021 Data on 214 parameters, including clinical characteristics, angiographic findings, laboratory and therapeutic findings, financial costs, and in-hospital mortality, were obtained for all patients Analyses were performed on the complete dataset of 1804 patients Of these patients, 694 385 were admitted for ST-segment elevation myocardial infarction STEMI and 1110 615 were admitted for non-ST-elevation NSTE-ACS [779 with NSTE myocardial infarction NSTE-MI and 331 with unstable angina UA] Almost all patients 99 underwent coronary angiography Primary percutaneous coronary intervention PCI was performed in 934 of STEMI patients and 745 of NSTE-ACS patients Patients with NSTE-MI had the longest total hospital stay 81 ± 91 days and highest financial costs 85795 ± 71732 euros In-hospital mortality was 12 in UA, 62 in NSTE-MI, and 109 in STEMI patients Age older than 75 years, pre-hospital cardiac arrest and/or mechanical ventilation, subacute STEMI, and ejection fraction below 40 were the most powerful predictors of in-hospital mortality as assessed by multivariate analyses The in-hospital mortality of unselected NSTE-MI and STEMI patients in daily practice is not low despite very good implementation of guideline-recommended therapy with a high rate of revascularization The highest financial costs are associated with NSTE-MILong-term follow-up after primary percutaneous coronary intervention pPCI for ST-segment elevation myocardial infarction STEMI beyond 5 years is poorly described There are no risk-stratification systems available for routine use This retrospective, academic, two-centre analysis included consecutive patients who presented with acute STEMI between March 2008 and December 2019 In total, 5263 patients underwent pPCI; all patients were included in the analysis only once Baseline characteristics were gathered from prospective local registries and based on initial hospitalization The study enrolled 5263 patients who had been treated with pPCI; it found that cardiovascular mortality was the most frequent cause of death 650 on long-term follow-up to 12 years  https//wwwselleckchemcom/products/CAL-101html  Myocardial infarction associated mortality was 272 Cardiovascular mortality was dominant, including in the landmark analysis beyond 1 year Multivariate analysis identified significant predictors for long-term cardiovascular mortality age, history of diabetes mellitus, history of renal insufficiency, history of heart failure, Killip class, and successful pPCI at presentation