In the tibial-axial plane, the mean of prosthetic alignment in the anteroposterior plane was 40° in the Robot group and 67° in the Manual group plt;001 The rate of outliers for tibial-axial alignment in the Robot group was significantly less than in the Manual group plt;001 There were no statistically significant differences in prosthetic translation in the proximal-distal, anterior-posterior and medial-lateral orientations between the groups
 
  In a radiologic study using 3DCT, robotic-assisted TKA reduced the outliers for rotational alignment of the tibial prosthesis in comparison to conventional TKA, which can lead to improved tracking of the femoral-tibial bearing surfaces
 In a radiologic study using 3DCT, robotic-assisted TKA reduced the outliers for rotational alignment of the tibial prosthesis in comparison to conventional TKA, which can lead to improved tracking of the femoral-tibial bearing surfacesThe commonsense view is that a lucid dream starts when the dreamer realizes that they are currently dreaming The notion of realization, however, has been accepted at face value, with little consideration of whether the dreamer realizes that they are dreaming in the sense of actual reasoning, or if it is a mere epiphenomenon of lucid dream initiation This article offers a solution to this problem by, first, arguing that the transition to lucidity can occur as a result of successful reasoning, and second, building a model of this reasoning in terms of probabilistic reasoning The established Bayesian model explains realization in lucid dreams taking under consideration two factors the beliefs that the dreamer holds on what is generally probable and improbable, and the dreamer's admissibility of being in a dream Defended against important objections, the model offers an explanation of lucid dream initiation, relevant for future research on dreaming
  The terminology of "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" NIFTP was introduced in 2016; and estimated to cause significant effects in the clinical management of thyroid nodules The aim of our study is to review our cases that were previously diagnosed as non-invasive encapsulated follicular variant PTC NI/E-FVPTC which are compatible with NIFTP and to correlate their follow-up
 
  All thyroidectomy cases evaluated in the last 15years were screened, and possible NIFTP cases were determined among patients with NI/E-FVPTC and they were re-examined microscopically Revised histopathological criteria were used for the retrospective diagnosis of NIFTP Histopathological findings were correlated to follow up information
 
  Totally 2138 cases had been previously diagnosed with PTC; 481 225 of them were FVPTC After microscopic reevaluation of potential NIFTP cases, 84 cases 39 received final diagnosis of NIFTP 786 of NIFTP patients were female F/M 66/18; mean age was 490, tumor diameter was 227mm and follow-up time was 664months 179 of NIFTP cases were multifocal and 131 were bilateral No recurrence, lymph node involvement or distant metastasis was detected in any of the patients who were followed up The mean age of the patients who had total thyroidectomy and received RAI was significantly higher than those who did not
 
  Although conservative treatment of NIFTP with lobectomy is recommended, age of the patients has been continuing to be the most important determinant for the clinicians to decide on total thyroidectomy and RAI ablation therapy at our institution
 Although conservative treatment of NIFTP with lobectomy is recommended, age of the patients has been continuing to be the most important determinant for the clinicians to decide on total thyroidectomy and RAI ablation therapy at our institutionThe t9;22q34;q112, also known as the Philadelphia Ph chromosome, results in BCR-ABL1 fusion residing on the derivative chromosome 22 This translocation is characteristic of chronic myeloid leukemia, but also can occur in a substantial subset of B acute lymphoblastic leukemia B-ALL cases Ph-like B-ALL has a gene expression profile similar to that of BCR-ABL1 positive/Ph-positive B-ALL, but by definition Ph-like B-ALL does not have the sentinel BCR-ABL1 or the Ph chromosome About half of Ph-like B-ALL cases carry CRLF2 rearrangements Rare cases of de novo B-ALL with co-occurrence of BCR-ABL1 and CRLF2 rearrangements have been described To our knowledge, this is the first report of concurrent BCR-ABL1 and CRLF2 rearrangements in blast phase of chronic myeloid leukemia In this patient, CRLF2 rearrangement was acquired at the time of disease progression to B-lymphoblast phase of chronic myeloid leukemia We also review the literature and discuss the distinct clinicopathologic, and genomic characteristics of CRLF2 rearranged B-ALL
  Sleep Apnea Syndrome SAS is a multimorbid chronic disease with individual and societal deleterious consequences Polysomnography PSG is the multi-parametric reference diagnostic tool that allows a manual quantification of the apnea-hypopnea index AHI to assess SAS severity The burden of SAS is affecting nearly one billion people worldwide explaining that SAS remains largely under-diagnosed and undertreated The development of an easy to use and automatic solution for early detection and screening of SAS is highly desirable
 
  We proposed an Accelerometry-Derived Respiratory index ADR solution based on a dual accelerometry system for airflow estimation included in a machine learning process It calculated the AHI thanks to a RUSBoosted Tree model and used physiological and explanatory specifically developed features The performances of this method were evaluated against a configuration using gold-standard PSG signals on a database of 28 subjects
 
  The AHI estimation accuracy, specificity and sensitivity of the ADR index were 89, 100 and 80 respectively  https//wwwselleckchemcom/products/tno155html  The added value of the specifically developed features was also demonstrated
 
  Overnight physiological monitoring with the proposed ADR solution using a machine learning approach provided a clinically relevant estimate of AHI for SAS screening The physiological component of the solution has a real interest for improving performance and facilitating physician's adhesion to an automatic AHI estimation
 Overnight physiological monitoring with the proposed ADR solution using a machine learning approach provided a clinically relevant estimate of AHI for SAS screening The physiological component of the solution has a real interest for improving performance and facilitating physician's adhesion to an automatic AHI estimation
  Childbirth is a transcendent life experience but may also be a moment of great vulnerability, especially when it occurs outside the mother's country of origin
 
  To explore the perceptions and experiences of Spanish-speaking immigrant women regarding the healthcare they received during labour and childbirth in Santiago, Chile
 
  This qualitative, transcendental phenomenological research was performed at two maternity hospitals using purposive criterion sampling Eighteen individual and two group interviews were conducted The resulting information was transcribed and then coded and categorised using phenomenological analysis
 
  Six categories were extracted from the narratives which reflect a pragmatic relationship with the healthcare team that included a perception of 'justified' lack of care The mothers' exercise of autonomy was subjugated by power-knowledge relations between the women and caregiver that compelled them to refrain from expressing their needs and preferences out of fear of abuse The women reflect a need for a stronger focus on empowerment with an emphasis on gender and rightsThe Quality Ratio QR index was applied in Sepetiba Bay to integrate geochemical and microbiological parameters of the in situ microbial community in order to classify the ecological risk of sediments Total concentrations C of Hg, Cd, As, Pb, Cr, Cu and Zn indicators of the mixture of contaminants were determined at 26 stations and at a background area C0 to calculate the contamination factor CF = C/C0 and the degree of contamination ΣCF Enzymatic biomarkers of energy production into cell dehydrogenase - DHA and hydrolase of organic matter outside the cell esterases - EST were determined The QR, a function of the microbial term DHA/EST and the geochemical term TOC × ΣCF/fine-grained content, was able to segregate stations into the internal sector east of the bay with the largest continental contributions and the external sector west of the bay, proving its accessibility low-cost and fast and efficiency for assessing ecological riskThe use of Unmanned Aerial Systems UAS, aka drones images for mapping macro-litter in the environment have been exponentially increasing in the recent years In this work, we developed a multi-class Neural Network NN to automatically identify stranded plastic litter categories on an UAS-derived orthophoto The best results were assessed for items that did not have substantial intra-class colour variability, such as octopus pots and fishing ropes F-score = 61, on average Instead, performance was poor 37 for plastic bottles and fragments, due to their changing intra-class colours On average, the performance improved 24 when the binary detection litter/non-litter, F-Score = 73 was considered, however this approach did not discriminate the litter categories This work gives a new perspective for the automated litter detection on drone images, suggesting that colour-based approach can be used to improve the categorization of stranded litter on UAS orthophoto
  Relapsing-remitting multiple sclerosis RRMS is an autoimmune disorder of the central nervous system Dimethyl Fumarate is a disease-modifying medication used to treat RRMS patients that can induce lymphopenia We aimed to immunophenotype peripheral blood mononuclear cells PBMC in RRMS patients cross-sectionally and examine the characteristics and modifications of lymphopenia over time
 
  Characterization of PBMC was done by multiparametric flow cytometry Patients had been on treatment for up to 4 years and were grouped into lymphopenic DMF-L and non-lymphopenic DMF-N patients
 
  Lymphopenia affected the cell population changes over time, with other patient characteristics gender, age, and previous treatment status also having significant effects In both lymphopenic and non-lymphopenic patients, PBMC percentages were reduced over time While overall T and B cells frequencies were not affected, males, older patients and untreated patients had significant changes in B cell subpopulations over timehe immune profile of patients
 Our data provide evidence that under the same therapy, lymphopenia affects how the immunophenotype changes over time and can override the differences associated with other patient characteristics and possibly mask other significant changes in the immune profile of patientsThe use of planning policy to manage and create a healthy food environment has become a popular policy tool for local governments in England To date there has been no evaluation of their short-term impact on the built environment We assess if planning guidance restricting new fast food outlets within 400 m of a secondary school, influences the food environment in the local authority of Newcastle Upon Tyne, UK We have administrative data on all food outlets in Newcastle 3 years pre-intervention 2012-2015, the intervention year 2016, and three years' post-intervention 2016-2019 We employ a difference-in-difference approach comparing postcodes within the school fast food outlet exclusion zone to those outside the fast-food exclusion zones In the short term 3 years, planning guidance to limit the number of new fast-food outlets in a school exclusion zone did not have a statistically significant impact on the food environment when compared with a control zone