5 ULN vs ≥ 25 ULN correlated with RFS and CRR associated with a 5-years RFS rate and CRR of 76 vs 86 p = 0012 and 32 vs 59 p  ≤  0001, respectively
 
  LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratification
 LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratification
  To evaluate the impact of 5-alpha reductase inhibitors 5-ARIs on definitive treatment DT and pathological progression PP in patients on active surveillance AS for prostate cancer
 
  We identified 361 consecutive patients, from an IRB-approved database, on AS for prostate cancer with minimum 2years follow-up Patients were grouped into two cohorts, those using 5-ARIs 5-ARI; n = 119 or not using 5-ARIs no 5-ARI; n = 242 Primary and secondary endpoints were treatment-free survival TFS and PP-free survival PPFS, which were evaluated by Kaplan-Meier analysis Univariate and multivariable cox regression analysis were used to identify predictors for PP and DT A p value lt; 005 was considered statistically significant
 
  Baseline characteristics and the prostate biopsy rate were similar between the two groups Median range follow-up was 57 20-172 years Five-year and 10-year TFS was 92 and 59 for the 5-ARI group versus 80 and 51 for the no 5-ARI group p = 0005, respectively Five-year and 10-year PPFS was 77 and 41 for the 5-ARI group versus 70 and 32 for the no 5-ARI group p = 004, respectively Independent predictors for treatment and PP were not taking 5-ARIs p = 0005; p = 002, entry PSA gt; 25ng/mL p = 003; p = 001 and Gleason pattern 4 on initial biopsy p lt; 0001; p lt; 0001, respectively The main limitation is the retrospective study design
 
  5-ARIs reduces reclassification and cross-over to treatment in men on active surveillance for prostate cancer Further, taking 5-ARIs was an independent predictor for prostate cancer progression and definitive treatment
 5-ARIs reduces reclassification and cross-over to treatment in men on active surveillance for prostate cancer Further, taking 5-ARIs was an independent predictor for prostate cancer progression and definitive treatmentLeft ventricular dysfunction is a pathophysiologic characteristic of heart failure Impaired instrumental activities of daily living are associated with an elevated risk of mortality and heart failure in older adults Nevertheless, the relationship between these activities and left ventricular function changes remains unclear We determined whether instrumental activities of daily living are associated with subsequent left ventricular function changes in older cardiovascular disease patients This retrospective cohort study included 383 outpatients with cardiovascular disease 745 ± 53 years, 273 males Patients were divided according to the Frenchay activities index tertile and followed for six months after cardiovascular disease diagnosis The left ventricular ejection fraction and annular early diastolic velocity e' were measured for left ventricular systolic and diastolic function, respectively, at baseline and after one year After adjusting for confounders, changes in the left ventricular ejection fraction were not significantly different However, changes in the e' in the highest tertile group were significantly greater than in other groups In the general linear model with multiple regression analysis, Frenchay activities index independently predicted the absolute change in the e' In older cardiovascular disease patients, higher instrumental activities of daily living were associated with preserved left ventricular relaxationGastrointestinal GI bleeding worsens the outcomes of critically ill patients in the intensive care unit ICU Owing to a lack of corresponding data, we aimed to investigate whether GI bleeding during cardiovascular-ICU C-ICU admission in acute cardiovascular CV disease patients is a risk factor for subsequent CV events Totally, 492 consecutive C-ICU patients 409 acute coronary syndrome, 228 heart failure were grouped into GI bleeding n = 27; 12 upper GI and 15 lower GI and non-GI bleeding n = 465 groups Thirty-nine patients died or developed CV events during hospitalization, and 453 were followed up from the date of C-ICU discharge to evaluate subsequent major adverse CV events  https//wwwselleckchemcom/products/liraglutidehtml  The GI bleeding group had a higher Acute Physiology and Chronic Health Evaluation II score 202 ± 82 vs 151 ± 68, p  less then  0001, higher frequency of mechanical ventilator use 296 vs 131, p = 0039, and longer C-ICU admission duration 8 [5-16] days vs 5 [3-8] days, p  less then  0001 than the non-GI bleeding group The in-hospital mortality rate did not differ between the groups Of those who were followed-up, CV events after C-ICU discharge were identified in 346 and 143 of patients in the GI and non-GI bleeding groups, respectively, during a median follow-up period of 228 days log rank, p  less then  0001 GI bleeding was an independent risk factor for subsequent CV events adjusted hazard ratio 223, 95 confidence interval 106-471; p = 0035 GI bleeding during C-ICU admission was independently associated with subsequent CV events in such settingsRecording the electrical potentials of bioengineered cardiac tissue after transplantation would help to monitor the maturation of the tissue and detect adverse events such as arrhythmia However, a few studies have reported the measurement of myocardial tissue potentials in vivo under physiological conditions In this study, human-induced pluripotent stem cell-derived cardiomyocyte hiPSCM sheets were stacked and ectopically transplanted into the subcutaneous tissue of rats for culture in vivo Three months after transplantation, a flexible nanomesh sensor was implanted onto the hiPSCM tissue to record its surface electrical potentials under physiological conditions, ie, without the need for anesthetic agents that might adversely affect cardiomyocyte function The nanomesh sensor was able to record electrical potentials in non-sedated, ambulating animals for up to 48 h When compared with recordings made with conventional needle electrodes in anesthetized animals, the waveforms obtained with the nanomesh sensor showed less dispersion of waveform interval and waveform duration