Gut microbial β-glucuronidase gmGUS is involved in the disposition of many endogenous and exogenous compounds Preclinical studies have shown that inhibiting gmGUS activity affects drug disposition, resulting in reduced toxicity in the gastrointestinal tract GIT and enhanced systemic efficacy Additionally, manipulating gmGUS activity is expected to be effective in preventing/treating local or systemic diseases Although results from animal studies are promising, challenges remain in developing drugs by targeting gmGUS Here, we review the role of gmGUS in host health under physiological and pathological conditions, the impact of gmGUS on the disposition of phenolic compounds, models used to study gmGUS activity, and the perspectives and challenges in developing drugs by targeting gmGUSIrritant-induced asthma IIA is a phenotype of asthma caused by the inhalation of irritant agents Definite, probable, or possible IIA have been described, depending on the concentration of the inhaled irritants and the onset of respiratory symptoms respective to the time of exposure Definite IIA represents approximately 4 to 14 of all cases of new-onset work-related asthma Agents responsible for IIA can be encountered as fumes, gases, aerosols, or dusts The most frequent are chlorine, nitrogen oxides, sulfur dioxide, ammonia, acetic acid, solvents, and cleaning materials Although the diagnosis of definite IIA is based on a suggestive clinical history along with evidence of reversible airflow limitation and/or nonspecific bronchial hyperresponsiveness, possible IIA cannot be diagnosed with certainty because the relationship between exposure and the onset of symptoms is difficult to establish This article reviews the epidemiology, pathophysiology, diagnostic approach, and management of IIAElectron dynamics in water are of fundamental importance for a broad range of phenomena1-3, but their real-time study faces numerous conceptual and methodological challenges4-6 Here we introduce attosecond size-resolved cluster spectroscopy and build up a molecular-level understanding of the attosecond electron dynamics in water We measure the effect that the addition of single water molecules has on the photoionization time delays7-9 of water clusters We find a continuous increase of the delay for clusters containing up to four to five molecules and little change towards larger clusters We show that these delays are proportional to the spatial extension of the created electron hole, which first increases with cluster size and then partially localizes through the onset of structural disorder that is characteristic of large clusters and bulk liquid water These results indicate a previously unknown sensitivity of photoionization delays to electron-hole delocalization and indicate a direct link between electronic structure and attosecond photoionization dynamics Our results offer new perspectives for studying electron-hole delocalization and its attosecond dynamicsResveratrol RES, as a polyphenol natural plant extract, mainly accumulates in the root of Polygonum cuspidatum, which can alleviate liver injury in mammals Our study aims to explore the effects and potential mechanism of RES on lipid metabolism of red tilapia, and the effects of RES on liver structure, fat synthesis and metabolism of red tilapia were determined The present study designed four groups named as 8  fat 8CK, 10  fat 10  HF, 10  HF + RES and 10  HF + RES + EX527 selisistat The liver tissues of red tilapia were collected at 3 3 W, 6 6 W and 9 9 W weeks for parameter determination Compared to the normal diet group, the hepatocyte of tilapia showed nuclear shift and vacuoles of different sizes when fed a high-fat diet Meanwhile, the high-fat diet increased the contents of LDL, TC and TG significantly at 6 W, and significantly decreased the content of NAD+ at 9 W Compared to the high-fat group, the nuclei of tilapia fed with RES were increased and visible, the degree of steatosis and the number of vacuoles were both reduced At 3/6/9 W, RES significantly decreased the contents of LDL, TG and TMAO, and significantly increased the content of NAD+ A total of 1416 genes were up-regulated and 1928 genes were down-regulated in the group with added RES when compared to the 10  HF group The pathways related to lipid metabolism including PPAR signaling pathway have been enriched Interestingly, the expressions of sirt1, pparα, fabp7 and cpt1b genes were up-regulated in RES diet group, while the expressions of pparγ, me1, scd and lpl genes were down-regulated After the addition of an inhibitor EX527, the above indexes showed an opposite trend when compared to the group with added RES The overall results showed that the high-fat diet could cause fatty liver lesions in the liver of red tilapia, and RES could activate the sirt1 gene, regulate the PPARα/γ pathway and related genes, and thus regulate liver fat synthesis and metabolism leading to the alleviation of damage to liver tissueKnowledge about additive on alleviating the negative effects of fish exposed to cadmium Cd needs to be more identified in the aquaculture Therefore, the present study aims to investigate whether diet supplemented with astaxanthin could mitigate adverse effects on hepatic Cd deposition, oxidative, inflammatory and non-specific immune responses, and intestinal morphology of Trachinotus ovatus exposed to dietary Cd treatment Three isonitrogen-isolipid experimental diets supplemented with/without CdCl2/Astaxanthin were formulated to feed the T ovatus for 30 days Results demonstrated that considerably higher hepatic Cd level was found in two Cd supplementing groups compared to the control group p 005, while these data in the dietary Cd with astaxanthin group showed significantly higher than that in the dietary Cd without astaxanthin group p less then 005 On the contrary, hepatic malondialdehyde content in the dietary Cd group showed significantly higher than that in the control group and dietary Cd with astaxanthin group p less then 005 Significantly lower mid-intestine morphology parameters were obtained in the dietary Cd group than the control group p less then 005, while significantly higher data were found in the dietary Cd with astaxanthin group compared to the dietary Cd group p less then 005 These results indicated that astaxanthin could mitigate the inhibitory effects of Cd on the oxidative, inflammatory and non-specific immune responses, and intestinal morphology of T ovatus while not reduce the hepatic Cd depositionReel syndrome is a pacemaker lead early dislodgment, characterized by reeling-in of the leads without being damaged We herein present a case of an 86-year-old woman, with medical history of single chamber pacemaker implantation two years ago, admitted in cardiology department with complete AV block Chest-Xray revealed ventricular lead coiling around and behind the pacemaker device Urgent extraction of the previous pacemaker was performed; however, the lead damage made its repositioning unfeasible Successful implantation of single-chamber pacemaker has been made This clinical case highlights the importance of adequate follow-up to timely identify lead dislodgement, avoid lethal complications and lead fractureComplex Regional Pain Syndrome CRPS represents severe chronic pain, hypersensitivity, and inflammation induced by sensory-immune-vascular interactions after a small injury  https//wwwselleckchemcom/products/ve-821html  Since the therapy is unsatisfactory, there is a great need to identify novel drug targets Unbiased transcriptomic analysis of the dorsal root ganglia DRG was performed in a passive transfer-trauma mouse model, and the predicted pathways were confirmed by pharmacological interventions In the unilateral L3-5 DRGs 125 genes were differentially expressed in response to plantar incision and injecting IgG of CRPS patients These are related to inflammatory and immune responses, cytokines, chemokines and neuropeptides Pathway analysis revealed the involvement of Tumor Necrosis Factor TNF and Janus kinase JAK-STAT signaling The relevance of these pathways was proven by abolished CRPS IgG-induced hyperalgesia and reduced microglia and astrocyte markers in pain-associated central nervous system regions after treatment with the soluble TNF alpha receptor etanercept or JAK inhibitor tofacitinib These results provide the first evidence for CRPS-related neuroinflammation and abnormal cytokine signaling at the level of the primary sensory neurons in a translational mouse model and suggest that etanercept and tofacitinib might have drug repositioning potentials for CRPS-related painThe post-acute COVID-19 syndrome PACS is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase Current data suggests that at least 10 of people with previously documented infection may develop PACS, and up to 50-80 of prevalence is reported among survivors after hospital discharge This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2 This hypothesis will be argued from biological, clinical and public health view, addressing three main questions i does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS; ii do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases; iii is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory
  Late preterm antenatal corticosteroid administration has been associated with an increased risk of neonatal hypoglycemia The mechanism is thought to be secondary to transient fetal hyperinsulinemia, which may be more likely if delivery occurs during peak antenatal corticosteroid levels
 
  This study aimed to investigate whether there is a latency interval between antenatal corticosteroid administration and delivery that places neonates at the greatest risk of hypoglycemia
 
  This was a retrospective matched cohort study of pregnant women who received antenatal corticosteroid vs unexposed women between 34 0/7 and 36 6/7 weeks of gestation from 2016 to 2019 Unexposed women were those who did not receive antenatal corticosteroid matched according to gestational age at delivery, diabetes mellitus status, and maternal body mass index from 2010 to 2015 Latency periods from initial steroid administration to delivery were defined in grouped intervals until ≥72 hours The primary outcome was neonatal hypoglycemiaia in exposed women compared with unexposed women after adjustment; within this time frame, the highest risk was 24 to 47 hours after antenatal corticosteroid administration adjusted relative risk, 209; 95 confidence interval, 129-338
 
  In the late preterm period, the risk of neonatal hypoglycemia is the greatest in the latency period of 12 to 71 hours between steroid administration and delivery Neonates exposed to antenatal corticosteroids were more likely to experience severe hypoglycemia within 24 hours of life than unexposed neonates
 In the late preterm period, the risk of neonatal hypoglycemia is the greatest in the latency period of 12 to 71 hours between steroid administration and delivery Neonates exposed to antenatal corticosteroids were more likely to experience severe hypoglycemia within 24 hours of life than unexposed neonates