This study aimed to evaluate the anteroposterior diameters and cross-sectional areas of the dural sac and spinal cord in the thoracic spine, to elucidate the spinal cord occupation rate of the dural sac in these dynamic changes for each level using multidetector-row computed tomography MDCT
 
  Fifty patients with cervical or lumbar spinal disease were prospectively enrolled After preoperative myelography, MDCT was performed at maximum passive flexion and extension The anteroposterior diameter and cross-sectional area of the dural sac and spinal cord in the axial plane and the thoracic spinal cord length in the sagittal plane were measured  https//wwwselleckchemcom/products/purmorphaminehtml  The spinal cord occupation rate in the dural sac was calculated
 
  The spinal cord occupation rate of the dural sac in anteroposterior diameter was lower on flexion than on extension, with significant differences from the T1/T2 to T11/T12 levels p lt; 00001 The spinal cord occupation rate of the dural sac in cross-sectional area was lower on flexion than on extension, with significant differences except from T3/T4 to T6/T7 levels p lt; 001 There was a bimodal increase in the occupation rate with elevations at the cervicothoracic junction and thoracolumbar junction The thoracic spinal cord length on flexion was significantly longer than that on extension p lt; 00001
 
  The spinal cord occupation rate of the dural sac was lower on flexion than on extension, despite thoracic spine being considered a rigid region The dynamic changes in longitudinal stretching and shrinkage of the spinal cord affected the occupation rate
 The spinal cord occupation rate of the dural sac was lower on flexion than on extension, despite thoracic spine being considered a rigid region The dynamic changes in longitudinal stretching and shrinkage of the spinal cord affected the occupation rateThe severe form of coronavirus disease 19 COVID-19 is characterized by cytokine storm syndrome CSS and disseminated intravascular coagulation DIC Diabetes, obesity, and hypertension have, as minor common denominators, chronic low-grade inflammation and high plasma myeloperoxidase levels, which could be linked to pulmonary phagocytic hyperactivation and CSS The hyperactivation of M1 macrophages with a proinflammatory phenotype, which is linked to aerobic glycolysis, leads to the recruitment of monocytes, neutrophils, and platelets from circulating blood and plays a crucial role in thrombo-inflammation as recently demonstrated in COVID-19 through the formation of neutrophil extracellular traps and monocyte-platelet aggregates, which could be responsible for DIC The modulation of glucose availability for activated M1 macrophages by means of a eucaloric ketogenic diet EKD could represent a possible metabolic tool for reducing adenosine triphosphate production from aerobic glycolysis in the M1 macrophiet
  The aim of this study was to evaluate effect of Lactobacillus plantarum HT121 on serum lipid profile, gut microbiota, and liver transcriptome and metabolomics
 
  L plantarum HT121 was selected by screening of acid and bile salt tolerance and cholesterol assimilation assay Sprague Dawley rats were randomly divided into three groups and fed the respective diets for 7 wk normal chow diet NCD, high-cholesterol diet HCD, and high-cholesterol diet plus L plantarum HT121 HT121 After 7 wk, blood lipid profile was measured by enzyme-linked immunosorbent assay, gut microbiota was determined by 16 S rRNA sequencing, gene expression, and bile acids in liver were detected by transcriptome and metabolomics, respectively
 
  L plantarum HT121 feeding decreased serum triacylglycerols TGs, total cholesterol TC, and low-density lipoprotein LDL, and increased serum high-density lipoprotein levels HT121 treatment increased the α-diversity in the HT121 group to a level close to that in the NCD group, and restoriota and bile acid metabolism
 L plantarum HT121 can improve serum lipid profiles in a high-fat diet-induced rat model, which may be attributed to alteration in gut microbiota and bile acid metabolism
  The aim of this study was to investigate the association between percent contribution of ultra-processed foods to total dietary energy intake and measurements of body composition obtained using high-validity methods
 
  This was a cross-sectional study with 1525 adolescents 18 to 19 y of age from the second follow-up of the 1997/98 São Luís birth cohort, Brazil To evaluate nutritional status and body composition, the body mass index BMI-for-age was used, along with waist circumference, total and android body fat percentage, muscle mass, and the lean mass index LMI Food consumption was evaluated by a food frequency questionnaire Food items were grouped according to the level of processing as per the NOVA classification Through semi-structured questionnaires, sociodemographic and lifestyle data were abstracted Adjusted linear regression models were used to evaluate the associations between consumption of ultra-processed foods and body composition measurements
 
  Total average energy consumption was 29197 kcal, with 58 16349 kcal derived from natural or minimally processed foods and 37 11365 kcal from ultra-processed products In the adjusted analyses, BMI, muscle mass, and LMI were inversely associated with consumption of ultra-processed foods A 1 increase in the percent contribution of ultra-processed items to total dietary energy intake was associated with a 004 kg decrease in muscle mass β = -004; 95 confidence interval [CI], -006 to -002; P lt; 0001 and a 001 kg/m
  decrease in lean body mass β = -001; 95 CI, -002 to -001; P lt; 0001
 
  The contribution of ultra-processed foods to total dietary energy intake of Brazilian adolescents was associated with body composition, especially with decreasing lean body mass
 The contribution of ultra-processed foods to total dietary energy intake of Brazilian adolescents was associated with body composition, especially with decreasing lean body massDespite the great promise of immune checkpoint blockade ICB therapy for cancer treatment, the currently available options for ICB treatment pose major clinical challenges, including the risk of severe systemic autoimmune responses Here, we developed a novel localized delivery platform, immuno-bioglue imuGlue, which is inspired by the intrinsic underwater adhesion properties of marine mussels and can allow the optimal retention of anti-PD-L1 drugs at tumor sites and the on-demand release of drugs in response to the tumor microenvironment Using a triple-negative breast cancer and melanoma models, we found that imuGlue could significantly enhance anti-tumor efficacy by eliciting a robust T cell-mediated immune response while reducing systemic toxicity by preventing the rapid diffusion of anti-PD-L1 drugs into the systemic circulation and other tissues It was also demonstrated that imuGlue could be successfully utilized for combination therapy with other immunomodulatory drugs to enhance the anti-tumor efficacy of ICB-based immunotherapy, demonstrating its versatility as a new treatment option for cancer immunotherapy