1 To evaluate the diagnostic performance of radiomics in differentiating high-grade glioma from brain metastasis and how to improve the model 2 To assess the methodological quality of radiomics studies and explore ways of embracing the clinical application of radiomics Studies using radiomics to differentiate high-grade glioma from brain metastasis published by 26 July 2021 were systematically reviewed Methodological quality and risk of bias were assessed using the Radiomics Quality Score RQS system and Quality Assessment of Diagnostic Accuracy Studies-2 QUADAS-2 tool, respectively Pooled sensitivity and specificity of the radiomics model were also calculated Seventeen studies combining 1,717 patients were included in the systematic review, of which 10 studies without data leakage suspicion were employed for the quantitative statistical analysis The average RQS was 513 1425 of total, with substantial or almost perfect inter-rater agreements The inclusion of clinical features in the r radiomics in combination with clinical features in differentiating high-grade gliomas from brain metastasis needs further validation • The pooled sensitivity and specificity of radiomics for differentiating high-grade gliomas from brain metastasis were 84 and 84, respectively • Avoiding potential data leakage by adopting an intensive and standardized workflow is essential to improve the quality and generalizability of the radiomics model • The application of radiomics in combination with clinical features in differentiating high-grade gliomas from brain metastasis needs further validationRaman spectroscopy is an emerging tool in the research and diagnosis of different diseases, including neurodegenerative disorders In this work, blood serum samples collected from healthy controls and dementia patients were analysed by Raman spectroscopy to develop a classification model for the diagnosis of dementia of Alzheimer's type DAT Raman spectra were processed by means of multivariate tools for multivariate analysis Lower concentration levels of carotenoids were detected in blood serum from patients, which allowed for a good discrimination with respect to controls, such as 93 of correct predictions on the test set with random forest We also hypothesize that carotenoid levels might be informative about the severity and progression of the disease, since the intensity of carotenoid signals decreased from the early stage to more severe patients These encouraging results suggest the possibility to use Raman spectroscopy for the analysis of alternative biofluids eg https//wwwselleckchemcom/products/genipinhtml saliva and the unobtrusive diagnosis of other neurodegenerative disordersWe report herein a multicentre retrospective analysis of 192 consecutive patients with symptomatic refractory/relapsed multiple myeloma RRMM treated with daratumumab in combination with bortezomib or lenalidomide as salvage therapy at 9 haematological centres in Puglia Choice of both regimens was based on previous treatment and/or physicians' preference Considering the under-representation of older patients very old patient ≥ 80 years in clinical trials and the prognostic and predictive importance and value of frailty status, here, we further characterised the patient cohort by age The overall response rate ORR was generally lower than what was previously reported in the CASTOR ORR 726 vs 85 and POLLUX ORR 865 vs 93 trials The lower ORR in our analysis compared to the CASTOR and POLLUX trials could be related to a less selected population Similarly, amongst very old patients, the ORR was encouraging ORR to treatment with DVd daratumumab + bortezomib + dexamethasone was 667, and ORR to treatment with DRd daratumumab + lenalidomide + dexamethasone was 923 Median TTP time to progression was 108 months 1-year TTP 447; 2-year TTP 253 in the DVd group; median TTP was not reached in the DRd group 1-year TTP 827; 2-year TTP 714 Median OS overall survival was not reached either in the DRd group 1-year OS 859; 2-year OS 737 or the DVd group 1-year OS 702; 2-year OS 589 Cancer is the second leading cause of death among women in the United States Previous studies demonstrate a higher prevalence of cancer among female orthopaedic surgeons This study aimed to provide an updated prevalence of breast and all-cause cancer among female orthopaedic surgeons using a larger and more current study population We distributed surveys to female orthopaedic surgeons in national orthopaedic specialty societies Six hundred seventy-two survey responses were collected We calculated standardized prevalence ratios SPRs and 95 confidence intervals CIs based on gender-specific, race-specific, and age-specific cancer prevalence statistics in the US population We compared the distribution of breast cancer risk factors with that of women in the 2018 and 2009 California Health Interview Survey Fifty-one of the 672 surveyed surgeons reported a diagnosis of invasive cancer Twenty reported breast cancer with a prevalence higher among female orthopaedic surgeons compared with the US female population SPR 289, 95 CI 216 to 381, P lt; 0001 The breast cancer prevalence was also higher among orthopaedic surgeons compared with the US female population SPR 397, 95 CI 243 to 614, P = 0003 The increased prevalence of breast and all-cause cancer among a larger and more diverse cohort of female orthopaedic surgeons confirms previous studies and provides an update regarding a concerning public health issue within this specialty The increased prevalence of breast and all-cause cancer among a larger and more diverse cohort of female orthopaedic surgeons confirms previous studies and provides an update regarding a concerning public health issue within this specialtyEvidence is emerging that immune responses not only play a part in the central nervous system CNS in diseases but may also be relevant for healthy conditions We discovered a major role for the interleukin-4 IL-4/IL-4 receptor alpha IL-4Rα signaling pathway in synaptic processes, as indicated by transcriptome analysis in IL-4Rα-deficient mice and human neurons with/without IL-4 treatment Moreover, IL-4Rα is expressed presynaptically, and locally available IL-4 regulates synaptic transmission We found reduced synaptic vesicle pools, altered postsynaptic currents, and a higher excitatory drive in cortical networks of IL-4Rα-deficient neurons Acute effects of IL-4 treatment on postsynaptic currents in wild-type neurons were mediated via PKCγ signaling release and led to increased inhibitory activity supporting the findings in IL-4Rα-deficient neurons In fact, the deficiency of IL-4Rα resulted in increased network activity in vivo, accompanied by altered exploration and anxiety-related learning behavior; general learning and memory was unchanged In conclusion, neuronal IL-4Rα and its presynaptic prevalence appear relevant for maintaining homeostasis of CNS synaptic functionProphylactic creatine treatment may reduce hypoxic brain injury due to its ability to sustain intracellular ATP levels thereby reducing oxidative and metabolic stress responses during oxygen deprivation Using microdialysis, we investigated the real-time in vivo effects of fetal creatine supplementation on cerebral metabolism following acute in utero hypoxia caused by umbilical cord occlusion UCO Fetal sheep 118 days' gestational age dGA were implanted with an inflatable Silastic cuff around the umbilical cord and a microdialysis probe inserted into the right cerebral hemisphere for interstitial fluid sampling Creatine 6 mg kg-1 h-1 or saline was continuously infused intravenously from 122 dGA At 131 dGA, a 10 min UCO was induced Hourly microdialysis samples were obtained from -24 to 72 h post-UCO and analysed for percentage change of hydroxyl radicals • OH and interstitial metabolites lactate, pyruvate, glutamate, glycerol, glycine Histochemical markers of protein and lipid oxidation were atreatment for fetal hypoxia Fetal sheep instrumented with a cerebral microdialysis probe were continuously infused with or without creatine-monohydrate for 10 days before induction of 10 min umbilical cord occlusion UCO; 131 days' gestation Cerebral interstitial fluid was collected up to 72 h following UCO Prior to UCO, fetal creatine supplementation reduced interstitial cerebral pyruvate and glycerol concentrations Fetal creatine supplementation reduced cerebral hydroxyl radical efflux up to 24 h post-UCO Fetuses with higher arterial creatine concentrations before UCO and reduced levels of systemic hypoxaemia during UCO were associated with reduced cerebral interstitial pyruvate, lactate and • OH following UCO Creatine supplementation leads to some improvements in cerebral bioenergetics following in utero acute hypoxia There is a paucity of literature investigating the relationship between patellar fracture and player performance of professional soccer players following return to play RTP Our goal is to determine the rate of RTP, time to RTP, and effect on player performance following patellar fracture Twenty-one elite-level European professional soccer players who sustained a patellar fracture between 1999 and 2018 were identified via a publicly accessible database Athletes with patellar fracture were matched to controls by age, height, years played in the league, season of injury, and position Change in performance metrics between one season prior to injury and the following four seasons after injury were compared Players with patellar fracture were absent for a mean 20795±13555days and 1681±3179 games Fifteen 71 players returned to play after injury with 67 returning within 1 season after injury Injured players did not demonstrate significant change in performance metrics at any of the follow-up ti not demonstrate a significant decline in performance as demonstrated by games played, total minutes played per season, minutes per game, assists, and goals 1 season after injury Attackers played fewer minutes during the season of and 2 seasons after the initial injury To assess the efficacy and safety of selective serotonin reuptake inhibitors SSRIs and selective noradrenaline reuptake inhibitors SNRIs in comparison with various control contingencies eg pill placebo and cognitive behavioral treatment for pediatric anxiety disorders Additionally, we wanted to investigate whether serious adverse events or adverse events are more common with medication treatment compared with pill placebo Studies were selected if they were randomized controlled trials evaluating SSRIs or SNRIs Eligible studies included participants aged 17 years or younger Eleven studies were included, with 2122 participants Primary outcomes were 1 remission, 2 a continuous scale such as the Social Phobia and Anxiety Inventory for Children and 3 serious adverse events We also calculated number needed to treat and number needed to harm SSRIs and SNRIs are an effective treatment of childhood anxiety disorders and are superior to pill placebo While the risk of serious adverse events was low with SSRI/SNRI treatment, there was an increased risk of experiencing behavioral activation with SSRI/SNRI treatment