Background Aeroallergens and food allergens play a key role in the pathogenesis of asthma; they are the target for future immunotherapy worldwide. Food allergens have been studied often in Egypt, but data are defective concerning the prevalent Egyptian aeroallergens that can be affected by the climatic conditions in Egypt. So, our study aimed to explore the dominant sensitizing aeroallergens in Egyptian patients with bronchial asthma. Methods Cross-sectional study performed on 122 Egyptian asthmatic patients. Sera from all patients were examined by enzyme allegro sorbent test (EAST) method for specific IgE to a panel of 18 inhaled allergens. Results Positive specific IgE to aeroallergens was detected in 43.44% of our patients. German cockroach (18.9%) was the most frequent sensitizing aeroallergen amongst our asthmatic patients, followed by the fungal allergens (15.57%) and house dust mites (HDMs) (13.93%). Conclusion German cockroach, fungi, and house dust mite are the chief sensitizing aeroallergens in Egyptian asthmatic patients. © 2020 The Author.Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common cause of death in patients with NF1. Central nervous system malignancies rarely occur. So far, the occurrence of spinal cord malignancies is exceedingly rare. Herein, we report a rare case of a 69-year-old male with NF1 following tumor resection twice for cutaneous MPNSTs developing intramedullary diffuse astrocytoma in the conus medullaris, which initially presented with traumatic spinal cord injury associated with a compression fracture from fall. Contrast-enhanced magnetic resonance imaging and biopsy of the spinal cord were required to establish the final diagnosis. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.Although brain metastases from bone and soft tissue sarcoma are uncommon, advances in sarcoma treatment have led to an increasing incidence of them. We present a 23-year-old male with a history of metastatic femoral osteosarcoma, who presented with headache and unsteady gait and was diagnosed with a cerebellar metastasis. CT scan revealed a mass in the left cerebellar parenchyma with large intralesional central calcification and perilesional edema. Corticosteroid treatment led to neurological symptoms resolution, with a rapid tapering. The patient had also lung metastases and we opted to administer systemic treatment with the tyrosine kinase inhibitor cabozantinib. Given the relative radioresistance of osteosarcomas, the patient did not receive radiation therapy. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.Trifurcation is rare anatomical variant of the common carotid artery (CCA) termination. Knowledge of such alteration may prevent from the unintentional complications and influence on the course of various invasive medical procedures carried in the neck region. The best way to assess anatomy of neck arteries is computed tomography angiography (CTA). In this article we present a case of 64-year old male patient, who was admitted to the department with a chronic headaches and dizziness. CTA revealed a trifurcation of the right common carotid artery into internal carotid artery and two branches of external carotid artery. The aneurysm of the proximal part of Vertebral Artery was also observed and it was considered as a cause of the symptoms which should not be related to the anatomical variety of the CCA. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.Isolated trapezoid fractures have been rarely reported in the literature and are occult on routine radiography. Previously described cases have utilized computed tomography (CT) to make this diagnosis; however, magnetic resonance imaging (MRI) is better for soft tissue evaluation and can detect fractures which may be occult on CT. We report 4 cases of isolated trapezoid fractures diagnosed by MRI in 4 males after remote trauma, ages ranging from 19 to 62. In each case, initial work-up with radiography, and one case with CT, was negative for a fracture but an MRI was ultimately obtained due to high clinical suspicion, resulting in the diagnosis of an isolated trapezoid fracture. Based on literature review, these are the first cases of isolated trapezoid fracture diagnosed by MRI. MRI offers several advantages over CT and is more valuable in cases of suspected occult fracture, given the ability to evaluate soft tissue and ligamentous injuries. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.Few cases of intermediate cuneiform osteochondrosis have been described in the literature. In this report we present a case of a 9-year-old boy with a 2-month history of right foot pain and edema, especially near the third metatarsal, without previous trauma. Also, there were no signs of inflammation, erythema, or fever. Sonrotoclax mouse Magnetic resonance imaging (MRI) showed bone edema, mild sclerosis, and volumetric reduction of the intermediate cuneiform. Nonsteroidal anti-inflammatory medication was prescribed as treatment. Symptoms remitted spontaneously after 2 weeks. The pain did not return, and the patient was asymptomatic after 3 months. Imaging studies such as X-ray, CT, and MRI are important to identify this condition and may avoid unnecessary tests and treatments such as laboratory exams, scintigraphy, and bone biopsies. Due to the benign nature as well as the possibility of it presenting with no symptoms, we believe that it may be considered as a variant of bone maturation or a self-limited condition. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.Background Metastatic osteosarcoma with direct cardiac involvement is an exceptionally rare finding. Reliable detection of cardiac metastases is known to be crucial for patients therapy and prognosis. Case Summary In a 10-year-old boy affected by osteosarcoma of the left femur, a baseline Fluorine-18-fluorodeoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) was performed to assess the full extent of disease. Whole-body scan detected numerous bone metastases together with a single pulmonary metastasis. Moreover, increased tracer uptake was observed in the intracavitary right cardiac ventricle in the position of a subtle spot of calcification. Because of nondetectability of a cavitary lesion on echocardiography, cardiac magnetic resonance imaging (CMRI) examination was performed to evaluate cardiac 18F-FDG PET/CT finding. CMRI revealed a small nodule in the right ventricle attached to the trabeculae, highly suspicious of a direct cardiac metastasis. After 4 cycles of chemotherapy, complete regression of tracer uptake of the lesion was observed on a follow-up 18F-FDG PET/CT scan.