The incidence of LARS was 826 n = 109/132, which was minor in 26/132 197 and major in 83/132 629 The most common symptoms were incontinence to flatus n = 86/132; 652 and defaecatory clustering 88/132; 667 In a multivariate model, predictors of major LARS were 1 cm decrease in tumor height above the anal verge OR = 1290, 95 CI 1101,1511; and an ASA grade greater than 1 OR = 2920, 95 CI 1239, 6883 Treatment allocation laparoscopic vs robotic did not predict major LARS CONCLUSIONS LARS is a common after rectal cancer surgery and patients should be appropriately counselled preoperatively, particularly before surgery for low tumors or in comorbid populationsOBJECTIVE To systematically review studies reporting survival data following neoadjuvant chemoradiation and orthotopic liver transplantation NCR-OLT for unresectable perihilar cholangiocarcinoma pCC BACKGROUND Despite survival improvements for other cancers, the prognosis of pCC remains dismal Since publication of the Mayo protocol in 2000, increasing numbers of series globally are reporting outcomes after NCR-OLT METHODS MEDLINE, EMBASE, Scopus, and Web of Science databases were searched from January 2000 to February 2019 A meta-analysis of proportions was conducted, pooling 1, 3-, and 5-year overall survival and recurrence rates following NCR-OLT across centers Per protocol and intention to treat data were interrogated Meta-regression was used to evaluate PSC as a confounder affecting survival RESULTS Twenty studies comprising 428 patients were eligible for analysis No RCTs were retrieved; the majority of studies were noncomparative cohort studies The pooled 1, 3-, and 5-year overall survival rates following OLT without neoadjuvant therapy were 712 95 CI 622-794, 480 95 CI 350-609, and 316 95 CI 231-407  https//wwwselleckchemcom/products/pkm2-inhibitor-compound-3khtml  These improved to 828 95 CI 730-908, 655 95 CI 487-805, and 651 95 CI 551-745 if neoadjuvant chemoradiation was completed Pooled recurrence after 3 years was 241 95 CI 179-309 with neoadjuvant chemoradiation, 517 95 CI 338-694 without CONCLUSIONS In unresectable pCC, NCR-OLT confers long-term survival in highly selected patients able to complete neoadjuvant chemoradiation followed by transplantation PSC patients appear to have the most favorable outcomes A high recurrence rate is of concern when considering extending national graft selection policy to pCCBACKGROUND Body proportion is an important symbol of human biology The aim of the present study was to examine the association of components of height with BMI and blood pressure BP among young adults METHODS A total of 4135 college students 2040 males and 2095 females aged 19-22 years participated in the study All subjects were classified into four groups Q1-Q4 according to their quartiles of height, sitting height and leg length, respectively, comparisons of BMI, SBP and DBP among the four groups were made RESULTS BMI is positively associated with sitting height and inversely associated with leg length, and the BP level is associated with sitting height rather than leg length BMI and BP level of young adults are also associated with their body proportion, subjects with high sitting height ratio SHR = sitting height/height × 100 had higher BMI and BP level, and more likely to have overweight/obesity and high BP CONCLUSION BMI and BP level of young adults are associated with their components of height, young adults with longer sitting height and higher SHR should be given special attention in the prevention of hypertension in their future livesOBJECTIVE The aim of the study was to determine whether oxytocin for induction or augmentation of labor impacts the incidence or persistence of pelvic floor symptoms and support 5 to 10 weeks after first vaginal delivery METHODS Participants in this prospective cohort study were nulliparous women 18 years or older that delivered vaginally at 37 weeks gestation or more and completed the Epidemiology of Prolapse and Incontinence Questionnaire EPIQ and the Pelvic Organ Prolapse Quantification examination in third trimester and 5 to 10 weeks postpartum We compared the incidence and persistence of symptomatic EPIQ domains and worse vaginal support maximal vaginal descent ≥0 cm between women who received oxytocin with those that did not with or without prostaglandin or mechanical methods in both groups We performed modified binomial regression to calculate adjusted relative risks of each outcome with 95 confidence intervals RESULTS The mean SD age of the 722 participants was 283 52 years; 20 were Hispanic There were no significant differences according to oxytocin exposure in either incidence or persistence of symptomatic EPIQ domains or worse vaginal support We found similar results in sensitivity analyses comparing women who received oxytocin as the sole pharmacologic agent to women who received no pharmacologic agent After adjusting for demographic and obstetric factors associated with incidence and persistence of symptoms and support, oxytocin exposure continued to have no effect CONCLUSIONS Oxytocin during labor does not significantly increase the risks for the incidence or persistence of pelvic floor symptoms or worse vaginal support in the early postpartum period, although power for less frequent outcomes was limitedOBJECTIVES Quantitative T1 relaxometry is the benchmark in imaging potential gadolinium deposition and known to be superior to semiquantitative signal intensity ratio analyses However, T1 relaxometry studies are rare, commonly limited to a few target structures, and reported results are inconsistentWe systematically investigated quantitative T1 relaxation times qT1 of a variety of brain nuclei after serial application of gadobutrol MATERIALS AND METHODS Retrospectively, qT1 measurements were performed in a patient cohort with a mean number of 11 gadobutrol applications n = 46 and compared with a control group with no prior gadolinium-based contrast agent administration n = 48 The following target structures were evaluated dentate nucleus, globus pallidus, thalamus, hippocampus, putamen, caudate, amygdala, and different white matter areas Subsequently, multivariate regression analysis with adjustment for age, presence of brain metastases and previous cerebral radiotherapy was performed RESULTS No assessed site revealed a significant correlation between qT1 and number of gadobutrol administrations in multivariate regression analysis However, a significant negative correlation between qT1 and age was found for the globus pallidus as well as anterior and lateral thalamus P less then 005 each CONCLUSIONS No T1 relaxation time shortening due to gadobutrol injection was found in any of the assessed brain structures after serial administration of 11 doses of gadobutrolProblems have been reported in the execution and development of motor skills and its treatment as a cause of cancer in children The purpose of this study was to examine the effect of the task-orientated rehabilitation program ToRP on motor skills of children with childhood cancer Following the consort guideline, 93 children 49 males and 44 females with pediatric cancer were randomized to either study n = 52; 1235 ± 343 years or control n = 41; 1189 ± 356 years groups The study group received ToRP, and the control group received a home-based therapeutic strategies program for 20 sessions Motor skill outcomes were assessed with Bruininks-Oseretsky Test of Motor Proficiency, Short Form BOTMP-SF by assessor who was blind to group allocation and interventions The groups were homogenous in terms of demographic characteristics and motor skills The study group showed a significant increase in both gross and fine motor skills P values for all subtests P  005 The ToRP appears to provide beneficial effects in improving motor skills at the early stages of rehabilitation for children with childhood cancerBalance is affected in numerous neurologic disorders, like stroke, multiple sclerosis and Parkinson's disease contributing to falls, and diminishing quality of life and functionality The mini-BESTest is one of the most recommended scales to detect balance disorders in people with Parkinson's disease, which has solid psychometric properties Unfortunately, this scale has not been validated in Chile and there are no other validated scales that can determine balance disorders in patients with Parkinson's disease to date The study objective was to validate the mini-BESTest scale in Chilean Parkinson's disease patients The translation and adaptation to Chilean Spanish of the mini-BESTest scale were made following a cross-cultural adaptation process, to then obtain face and content validity by an expert committee Afterwards, the demographic data and psychometric properties of internal consistency and ceiling and floor effects were measured with a sample of 50 subjects with Parkinson's disease Furthermore, 10 subjects of the sample were evaluated with the purpose of measuring inter rater reliability The scale presented a good internal consistency Cronbach's alpha = 0845, and an excellent inter rater reliability intraclass correlation coefficient = 097, no ceiling or floor effects were found The results of the face and content validity and psychometric properties are adequate, achieving the validation of the mini-BESTest scale for balance in Chilean people with Parkinson's diseaseHepatocellular carcinoma is the second leading cause of cancer-related death worldwide link2 Neural regulation plays an important role in the development of hepatocellular carcinoma, and activation of sympathetic nervous system can promote the migration and invasion of cancer cells However, little research has been conducted on how the vagus nerve influences hepatocellular carcinoma In this study, we found that the expression of vesicular acetylcholine transporter, a biomarker of vagus nerve, was associated with hepatocellular carcinoma patients' clinicopathological characteristics by immunohistochemistry Further, activation of muscarinic acetylcholine receptor 1 M1R promoted HepG2 and SMMC-7721 cells migration and invasion and epithelial-mesenchymal transition via PI3K/Akt pathway Moreover, inhibition of M1R by antagonist or shRNA suppressed hepatocellular carcinoma cells migration and invasion in vitro and in vivo, inhibited epithelial-mesenchymal transition and PI3K/Akt pathway link3 Therefore, these results indicate that activation of M1R promotes invasion of hepatocellular carcinoma through epithelial-mesenchymal transition and PI3K/Akt pathwayHepatocellular carcinoma HCC is a leading cause of cancer-related death worldwide Phytochemicals are important candidates for developing anticancer agents Ziyuglycoside II is a major active compound of Sanguisorba officinalis, which exhibits antiproliferation activity in several cancers; however, its action in HCC remains unknown In this study, we investigated the antitumor activity of ziyuglycoside II against HCC and explored the potential mechanisms We found that ziyuglycoside II exerts significant inhibitory effects on the viability and clonogenic activity of HCC cells The proliferation repression mediated by ziyuglycoside II was mainly due to increased apoptosis and reactive oxygen species accumulation, as well as a G0/G1 phase cell-cycle arrest Additionally, ziyuglycoside II markedly impaired HCC cell migration and invasion, two important steps during metastasis, and these suppressive effects may be attributed to the downregulation of matrix metalloproteinases MMP2 and MMP9 expression Moreover, ziyuglycoside II blocked the epidermal growth factor receptor/nuclear factor kappa-B EGFR/NF-kB signaling, which may contribute to its anticancer activity