56 mutations According to the 2016 World Health Organization diagnostic criteria, the patient was ultimately diagnosed with rare aCML with concomitant JAK2 V617F and SETBP1 mutations The patient received targeted therapy of ruxolitinib for 5 months and subsequently an additional four courses of combined hypomethylating therapy The patient exhibited an optimal response, with decreased spleen volume by approximately 35 after therapy and improved symptom scores after therapy In diagnosing primary bone marrow fibrosis, attention should be paid to the identification of MDS/MPN In addition to basic cell morphology, mutational analysis using next-generation sequencing plays an increasingly important role in the differential diagnosis aCML with concomitant JAK2 V617F and SETBP1 mutations has been rarely reported, and targeted therapy for mutated JAK2 may benefit patients, especially those not suitable recipients of hematopoietic stem cell transplantsAt the beginning of 2020 a respiratory diseased named COVID-19 rapidly spread worldwide Due to the presence of comorbidities and a greater susceptibility to infections, older adults are the population most affected by this pandemic An efficient pharmacological treatment for COVID-19 is not ready yet; in the meanwhile, a general quarantine has been initiated as a preventive action against the spread of the disease If on one side this countermeasure is slowing the spread of the virus, on the other side is also reducing the amount of physical activity Sedentariness is associated with numerous negative health outcomes and increase risk of fall, fractures and disabilities in older adults Models of physical inactivity have been widely studied in the past decades, and most studies agreed that is necessary to implement physical exercise such as walking, low load resistance or in bed exercise during periods of disuse to protect muscle mass and function from catabolic crisis Moreover, older adults have a blunted response to physical rehabilitation, and a combination of intense resistance training and nutrition are necessary to overcome the loss of in skeletal muscle due to disuseThe standing broad jump SBJ is a valid, reliable and feasible field-based test, which can evaluate explosive strength of the lower limbs and physical fitness This study aimed to provide normative data for the SBJ for male and female children and adolescents and describe differences in performance between age groups and genders A total number of 2140 children and adolescents, sampled in seven European nations have been included for analysis The SBJ was performed to derive percentile values for gender and each age group In general, males have greater jumping performance compared to females Data demonstrate a linear increase in the jumping distance for both males and females until adolescence However, such increase is evident in males up to 16-17 years old, whereas in females a plateau value is met at 12-13 years old, with a subsequent decrease in the jumping performance No differences were present in jumping performance between male and female children, however differences between male and female adolescents were evinced The study has provided percentile values useful to monitor the physical fitness status of children and adolescentsThe risk of a severe course of COVID-19 is increased in patients suffering with Neuromuscular disorders NMD due to the following comorbidities muscular weakness of the chest and diaphragm, use of ventilator supports and/or presence of tracheostoma, weak airway clearance, cardiac involvement, rhabdomyolysis, comoribities, steroid and immunosuppressant treatments NMD display varying levels of disability in people with the same diagnosis, thus it is difficult to give COVID-19 related general recommendations Present advicess were designed for patients, caregivers, general neurologists and non-specialist medical providers They address frequently asked questions and basic service requirements and are supported by a series of in-depth references In this truly unprecedented situation, the clinical management of neuromuscular patients during the COVID-19 epidemics - taking into account the related difficulties patients who have suspended ERT, difficulty in contacting the doctors, etc - we propose to use a telemedicine device, ie the AIGkit application AIGkit app, promoted and developed in 2018 by Fabrizio Seidita on behalf of the Italian Glycogenosis Association AIG The app was born to allow patients with Pompe disease to receive as far as possible continuous monitoring of their health The support of all colleagues of the Italian Association for Myology AIM should extend its use to all NMD patients and beyondThere is a lack of commercially available low-cost technologies to assess gait clinically in non-controlled environments As a consequence of this, there has been poor massification of motion measurement technologies that are both objective and reliable in nature  https//wwwselleckchemcom/products/iruplinalkibhtml  Advances about the study of gait and its interpretation in recent years using inertial sensors have allowed proposing acceptable alternatives for the development of portable and low-cost systems that contribute to people's health in places and institutions that cannot acquire or maintain the operation of commercially available systems A system based on a custom single Inertial Measurement Unit and a mobile application is proposed Thus, an investigation is carried out using methodologies and algorithms found in the literature in order to get the main gait events and the spatial-temporal gait parameters Twenty healthy Chilean subjects were assessed using a motion capture system simultaneously with the proposed tool The results show that it is possible to estimate temporal gait parameters with slight differences respect gold--standard We reach maximum mean differences of -235±502[step/min] for cadence, 003±004[sec] for stride time,002±003[sec] for step time, ±002[sec] for a single support time, 001±002[sec] for double support time and 001±003[m] for step length As a result of experimental findings, we propose a new technological tool that can perform gait analysis Our proposed system is user-friendly, low-cost, and portable Therefore, we suggest that it could be an attractive technological tool that healthcare professionals could harness to objectively measure gait in environments that are either within the community or controlled We also suggest that the tool could be used in countries where advanced clinical tools cannot be acquired Therefore, we propose in this paper that our system is an attractive, alternative system that can be used for gait analysis by health professionals worldwide