Genistein can obiviously promote the cell proliferation in the SW579 cells, which may be related to the action of GPR30. To study the anti-apoptotic effect of cyanidin-3-O-glucoside(C3 G) on H_2O_2-induced injury in human embryonic kidney(HEK)-293 cells. Hydrogen peroxide induced injury of HEK-293 cell was used as the research object. HEK-293 cells were pretreated with different concentrations of C3 G(1. 25, 5, 20 μmol/L). The anti-apoptotic effects of C3 G on injured cells were examined by the release rates of LDH and mitochondrial membrane potential(MMP). Western blot and qRT-PCR were used to detect the protein expression and mRNA expression of NF-κB P65. The result showed that the release rate of LDH was increased, MMP was decreased, the protein and mRNA of P65 was increased after H_2O_2 inducing. Whereas, the release rates of LDH were significantly lower than that of the injured group after 1. 25, 5, 20 μmol/L C3 G pretreatment of injured cells(P<0. 05). The MMP of C3 G group was significantly higher than injured group with concentration-dependent increases. The proteins and mRNA of P65 were also significantly lower than that of injured group(P<0. 05). Cyanidin-3-O-glucoside shows anti-apoptotic effect on H_2O_2-induced injury in HEK-293 cell. The mechanisms of anti-apoptotic effects may be to achieve by protecting cell biofilms, and inhibiting the activity of NF-κB signaling pathway.Cyanidin-3-O-glucoside shows anti-apoptotic effect on H_2O_2-induced injury in HEK-293 cell. The mechanisms of anti-apoptotic effects may be to achieve by protecting cell biofilms, and inhibiting the activity of NF-κB signaling pathway. To analyze the pollution characteristics of polycyclic aromatic hydrocarbons(PAHs) in atmospheric PM_(2. 5) in Lianhu district and Yanta district of Xi'an City. From 2016-2018, PM_(2. 5) samples were regularly collected at monitoring points in two districts of Xi'an City, and analyzed the content of naphthalene, acenaphthylene, fluorene, acenaphthene, phenanthrene, anthracene, fluoranthene, pyrene, chrysene, benz(a)anthracene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, dibenz(a, h)anthracene, benzo(g, h, i)perylene, indeno(1, 2, 3-cd)pyrene in the samples according to Ambient air and stationary source emissions-Determination of gas and particle-phase polycyclic aromatic hydrocarbons-High performance liquid chromatography(HJ 647-2013). FPH1 in vitro The test result were analyzed and evaluated according to different years, regions and seasons. The median total PAHs mass concentrations(ΣPAHs) in Lianhu district and Yanta district were 11. 68 and 12. 53 ng/m~3, respectively, with no sigs more serious.The degree of atmospheric PAHs pollution in Xi'an had decreased year by year, and PAHs pollution in winter was more serious. To investigate the internal exposure levels of manganese(Mn), cobalt(Co), selenium(Se) and molybdenum(Mo) in blood and urine among the general population in parts of Shaanxi Province, and thereby to analyze their population distribution characteristics. In 2017, a total of 720 subjects of general people aged 3-79 years were recruited from 5 counties in Shaanxi Province, by stratified random sampling method, blood and urine samples were collected, and the contents of Mn, Co, Se and Mo in blood and urine samples were detected by inductively coupled plasma mass spectrometry(ICP-MS). The test result were statistically analyzed according to different genders, regions and age groups. Among general people in Shaanxi Province, the median of Mn in blood and urine were separately 8. 43 and 0. 60 μg/L. The median of Mn in blood among males and females were 7. 99 and 8. 81 μg/L, the difference was statistically significant(P<0. 05), the difference of blood Mn between urban and rural areas was statistically s of blood Mo between urban and rural areas was statistically significant(P<0. 05). Within the same gender, all indexes in whole blood(except female blood Se) were statistically significant among age groups(P<0. 05). The differences of male urine Co, urine Se, urine Mo and female urine Co among age groups were statistically significant(P<0. 05). Among general population in Shaanxi Province, the Mn, Co, Se and Mo levels in blood and urine are varied by gender age and area, the blood Se level is relatively low.Among general population in Shaanxi Province, the Mn, Co, Se and Mo levels in blood and urine are varied by gender age and area, the blood Se level is relatively low. To investigate the contamination of benzo(a)pyrene in edible vegetable oil from Henan Province. A total of 1190 edible vegetable oil samples from Henan Province were collected. The concentration of benzo(a)pyrene was examined by high performance liquid chromatography. The concentration of benzo(a)pyrene in prepackaged edible vegetable oils was <0. 3-63. 5 μg/kg with an average of 1. 5 μg/kg. The detection rate of benzo(a)pyrene in samples was 80. 0%, and the over standard rate was 0. 6%. In terms of subclasses of vegetable oil, the sesame seed oil samples were most seriously contaminated with benzo(a)pyrene. The risk of the benzo(a)pyrene contamination of sesame seed oil produced by aqueous extraction method was higher than that by mechanical pressed method. The risk of benzo(a)pyrene contamination in sesame seed oil and rapeseed oil increased as the decrease of quality grade. The result suggested that the sesame seed oil produced by aqueous extraction method had high risk in benzo(a)pyrene contamination in Henan Province.The result suggested that the sesame seed oil produced by aqueous extraction method had high risk in benzo(a)pyrene contamination in Henan Province. To investigate the level of lead in cereals and related products from Zhejiang market, and to provide the preliminary assessment. Lead was detected in 4855 samples of cereals and related products during 2014-2019, food consumption data was taken from Zhejiang residents' consumption survey in 2015-2016. The total detection rate of lead in cereals and related products was 59. 03%, and the acceptance rate was 99. 3% when compared to the national food safety standards(GB 2762-2017). The average lead level in cereals and related products was 0. 031 mg/kg, high mean level was found in millet with 0. 049 mg/kg, low mean level was in grain cans with 0. 020 mg/kg. The average dietary exposure to lead via cereals and related products was 0. 16 μg/(kg·d), and 0. 45 μg/(kg·d) for high consumer(P97. 5). Lead in cereals and related products are at very low contamination levels, residents' average daily intake of lead from grains and products was low in Zhejiang Province, but measures are still needed to reduce lead in cereal products considering the adverse health effects of lead.

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