icular characteristics of affective states ie, valence but not arousal may "get under the skin" in daily life
  More than 40 million people are living with either mitral or aortic valve disease worldwide, and more than 180 000 heart valve replacement surgeries are performed each year in the US Transcatheter valve repair has emerged as an important therapeutic option for patients who are candidates for heart valve replacement
 
  All transcatheter valve therapies involve a multidisciplinary team of interventional cardiologists, cardiothoracic surgeons, radiologists, echocardiographers, nurses, and social workers, termed the heart team, to determine the optimal approach for managing each patient Transcatheter aortic valve implantation TAVI is an aortic valve replacement procedure that is performed percutaneously and is currently approved for patients with severe, symptomatic aortic stenosis in all surgical risk categories The TAVI procedure can be performed using a balloon-expandable or self-expanding valve In a low-risk cohort of patients PARTNER [Placement of Aortic Transcatheter Valves] 3 trial, the rates of tation, respectively Transcatheter valve therapies have expanded therapeutic options for patients, including for those who previously had no viable surgical optionsCyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years Several gene sequences for plant cyclic peptides have been discovered over the last two decades but it is only recently that we are beginning to understand the intricacies associated with their biosynthesis Recent studies have focussed on three main classes of plant derived cyclic peptides, namely orbitides, SFTI related peptides and cyclotides In this mini-review, we discuss the expansion of the known sequence and structural diversity in these families, insights into the enzymes involved in the biosynthesis, the exciting applications which includes a cyclotide currently in clinical trials for the treatment of multiple sclerosis, and new production methods that are being developed to realise the potential of plant cyclic peptides as pharmaceutical or agricultural agentsBioassays guided phytochemical investigations on the ethyl acetate-soluble fraction of the root material of Ballota pseudodictamnus L Benth led to the isolation of two new compounds, ballodiolic acid A 1 and ballodiolic acid B 2, along with three known compounds ballodiolic acid 3, ballotenic acid 4, and β-amyrin 5, which were also isolated for the first time from this species by using multiple chromatographic techniques The structures of the compounds 1-5 were determined by modern spectroscopic analysis including 1D and 2D NMR techniques and chemical studies In three separate experiments, the isolated compounds 1-5 demonstrated potent antioxidant scavenging activity, with IC50 values ranging from 0722-3410 μM in the hydroxyl radical •OH inhibitory activity test, 5810-14855 μM in the total ROS reactive oxygen species inhibitory activity test, and 623-6901 μM in the peroxynitrite ONOO- scavenging activity test With IC50 values of 0722 ± 003, 5810 ± 007, 623 ± 004 μM for •OH, total ROS, and scavenge ONOO-, respectively, ballodiolic acid B 2 showed the highest scavenging ability Antibacterial and antifungal behaviors were also exposed to the pure compounds 1-5 In contrast to compounds 4 and 5, compounds 1-3 were active against all bacterial strains studied, with a good zone of inhibition proving these as a potent antibacterial agent Similarly, compared to compounds 3-5, compounds 1 and 2 with a 47 percent and 45 percent respective inhibition zone were found to be more active against tested fungal strainsHeparanase Hpse is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains Its upregulated expression is implicated in tumor growth, metastasis and angiogenesis, thus making it an attractive target in cancer therapeutics Currently, a few small molecule inhibitors have been reported to inhibit Hpse, with promising oral administration and pharmacokinetic PK properties In the present study, a ligand-based pharmacophore model was generated from a dataset of well-known active small molecule Hpse inhibitors which were observed to display favorable PK properties The compounds from the InterBioScreen database of natural 69,034 and synthetic 195,469 molecules were first filtered for their drug-likeness and the pharmacophore model was used to screen the drug-like database The compounds acquired from screening were subjected to molecular docking with Heparanase, where two molecules used in pharmacophore generation were used as reference From the docking analysis, 33 compounds displayed higher docking scores than the reference and favorable interactions with the catalytic residues Complex interactions were further evaluated by molecular dynamics simulations to assess their stability over a period of 50 ns  https//wwwselleckchemcom/MEKhtml  Furthermore, the binding free energies of the 33 compounds revealed 2 natural and 2 synthetic compounds, with better binding affinities than reference molecules, and were, therefore, deemed as hits The hit compounds presented from this in silico investigation could act as potent Heparanase inhibitors and further serve as lead scaffolds to develop compounds targeting Heparanase upregulation in cancerPulmonary cystic echinococcosis remains a serious threat to public health A standardized, imaging-based classification method for pulmonary echinococcosis has not yet been developed despite the existence of a standardized ultrasound classification method and treatment plan for hepatic cystic echinococcosis Chest computed tomography CT images from 34 cases of pulmonary cystic echinococcosis with 46 lesions were used for classification based on the World Health Organization WHO standardized ultrasound classification of hepatic cystic echinococcosis CT findings were compared with intraoperative observations and postoperative pathological results to assess accuracy Pulmonary cystic echinococcosis was common in women 14/34, 412 and children 14/34, 412 with a single cyst 28/46, 609 Most lesions were classified as cystic echinococcosis 1CE1, 19/46 or cystic echinococcosis 3CE3, 21/46 Blood leukocytosis was mostly observed in CE3 lesions 100, 9/9 p less then 005 The preoperative CT diagnosis of pulmonary cystic echinococcosis had an accuracy rate of 100 The preoperative CT typing, and postoperative pathological typing had a coincidence rate of 978 45/46 Our study provided a classification method based on CT imaging for pulmonary cystic echinococcosis that can be used during pre-surgical planning to reduce patient's postoperative complications and mortalityIron oxide nanoparticles IONPs have played a pivotal role in the development of nanomedicine owing to their versatile functions at the nanoscale, which facilitates targeted delivery, high contrast imaging, and on-demand therapy Some biomedical inadequacies of IONPs on their own, such as the poor resolution of IONP-based Magnetic Resonance Imaging MRI, can be overcome by co-incorporating optical probes onto them, which can be either molecule- or nanoparticulate-based Optical probe incorporated IONPs, together with two prominent non-ionizing radiation sources ie, magnetic field and light, enable a myriad of biomedical applications from early detection to targeted treatment of various diseases In this context, many research articles are in the public domain on magneto-optical nanoparticles; discussed in detail are fabrication strategies for their application in the biomedical field; however, lacking is a comprehensive review on real-life applications in vivo, their toxicity, and the prospect of bench-to-bedside clinical studies Therefore, in this review, we focused on selecting such important nanocomposites where IONPs become the magnetic component, conjugated with various types of optical probes; we clearly classified them into class 1 to class 6 categories and present only in vivo studies In addition, we briefly discuss the potential toxicity of such nanocomposites and their respective challenges for clinical translationsFinding perspective on current events in an ancient and fabled landscapeUpdated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues Best of the Blog is a regular column to draw the attention of AJN readers to posts we think deserve a wider audience To read more, please visit wwwajnoffthechartscomThis article is one in a series in which contributing authors discuss how the United Nations UN Sustainable Development Goals SDGs are linked to everyday clinical issues; national public health emergencies; and other nursing issues, such as leadership, shared governance, and advocacy The 2030 Agenda for Sustainable Development, a 15-year plan of action to achieve the goals, was unanimously adopted by all UN member states in September 2015 and took effect on January 1, 2016 The Agenda consists of 17 SDGs addressing social, economic, and environmental determinants of health and 169 associated targets focused on five themes people, planet, peace, prosperity, and partnership The SDGs build on the work of the UN Millennium Development Goals, which were in effect from 2000 to 2015 The current article highlights SDG 11-making "cities and human settlements inclusive, safe, resilient and sustainable"
  The purpose of this evidence-based practice project was to reduce the incidence of pressure injuries PIs from the use of graduated compression stockings in patients on a gastrointestinal GI sarcoma surgery unit Before this project, the standard of care for preventing deep vein thrombosis DVT included the use of graduated compression stockings, anticoagulation therapy, and intermittent pneumatic compression devices We sought to examine the impact on PI and DVT risk of using only anticoagulation therapy and intermittent pneumatic compression devices
 
  The pilot phase of the project began in June 2017 when nurses on the GI sarcoma surgery unit initiated a practice change in which graduated compression stockings were removed during the 7 AM shift change and put back on the patient before bedtime Data on the incidence of DVTs and PIs were already being collected in our institution's electronic health record and safety intelligence reporting system The project team monitored the incidence of PIs and DVpression stockings use in postoperative patients throughout our institution In the 17 months after the pilot project was initiated, no PIs occurred among patients in the GI sarcoma surgery unit, which also maintained a zero rate of DVTs
 We found that the use of graduated compression stockings confers more risks than benefits for patients Our findings prompted the discontinuation of graduated compression stockings use in postoperative patients throughout our institution In the 17 months after the pilot project was initiated, no PIs occurred among patients in the GI sarcoma surgery unit, which also maintained a zero rate of DVTs