Chemically, safranal is a monoterpene aldehyde possessing a sweet fragrance. While exploring for the photoprotective properties of safranal, we learnt about the immense antioxidant potential of safranal. Investigation by various research groups established safranal as an anti-inflammatory, antidepressant, anxiolytic, antiasthamatic, antihypertensive, anticonvulsant, anticancer and antitussive and antigenotoxic agent. It has brought researchers over the world to explore the antioxidant benefits of saffron for human health. In the present paper, potential of safranal and its related molecules as radical scavenger in combating oxidative stress, diseased conditions is collated and the underlying mechanisms have been explained. Various cell lines and animal models used for study of Safranal have been discussed.Ovarian cancer is the most lethal gynecological cancer. Numerous subtypes exist, each with distinct risk factors and prognosis. What underlies these subtypes and their progression is not clear, although inflammation through NFκB may play a key role. We performed a study on a series of well-characterized in vitro ovarian cancer models including TOV21G, TOV112D and OV90 originally derived from clear cell, endometrioid and high grade serous carcinoma respectively. Cells were treated with 0-100 ng/ml TNFα over 6-72 h. The NFκB pathway was inhibited by a series of NFκB pathway inhibitors, 100μM PDTC, 1μM PS-1145 and 200nM TPCA and the influence on cellular viability and inflammation was measured via an MTS assay and qPCR respectively. TNFα stimulation of NFκB was confirmed via Western blot. We found TNFα facilitated continued growth of TOV21G and TOV112D cells in an NFκB independent method. In contrast, TNFα inhibited OV90 cell growth in an NFκB dependent manner. TNFα stimulated production of IL-6, IL-8, MCP-1 and RANTES on all three cells lines, but only IL-6 and IL-8 were via NFκB mediated mechanisms. These results indicate TNFα may have diverse effects mediated through both NFκB and non-NFκB pathways on ovarian cancer cells. Understanding the role for TNFα in each subtype may have significant implications for charting disease progression and designing personalized treatments.The main focus of current research is on the synthesis and anticorrosive activity of novel heterocyclic compounds tert-butyl 4-[(4-methyl phenyl) carbonyl] piperazine-1-carboxylate [TBMPCPC]. Electrochemical, quantum chemical, and surface characterization studies at elevated temperatures (303-333 K) for carbon steel in 1M HCl solution studied this molecule's corrosion inhibition property. It is observed from the results of electrochemical studies that the TBMPCPC may be able to effectively protect the steel plate surface with an inhibition efficiency of 91.5 % at 25 ppm in corrosive media. The corrosion inhibition depends on concentration, as concentration also increases inhibition efficiency due to the strong and spontaneous adsorption on the metal's surface. The Tafel polarization measurements concluded that the inhibitor works as a mixed form to protect the carbon steel in the bulk solution from corrosion. The adsorption of the TBMPCPC onto the metal surface was in reliable with the isothermal model of the Langmuir adsorption. The scanning electron microscopy clearly showed that the inhibitor was substantially deposited on the metal surface, indicating substantial inhibition. The surface morphology of carbon steel in the absence and existence of an inhibitor in 1 M HCl is also studied using the Atomic Force Microscopic method. Suicide, a major public health concern, is a leading cause of injury and death worldwide. The present study aims to assess suicidal behaviors and suicide risk among Bangladeshi people during COVID-19. A cross-sectional online survey was conducted from July 10 to July 20, 2020, involving 1,415 Bangladeshi residents ages 18 years or older. Data was collected via an anonymous online questionnaire. RepSox cost The Suicide Behaviors Questionnaire-Revised was used to assess suicide risk. The depression and anxiety subscales of the Depression Anxiety Stress Scale 21 were used to assess depression and anxiety. Logistic regression analyses and Pearson's correlation were performed to examine the association of variables. The prevalence of suicide ideation and planning among Bangladeshi people during the COVID-19 pandemic was 19.0% and 18.5%, respectively. Having suicidal risk during the COVID-19 pandemic was reported by 33.5% participants. Suicide risk was associated higher with females, divorced or widowed marital statuses and low educational attainment (i.e., secondary or below and higher secondary/diploma). Additionally, living in high COVID-19 prevalent areas, having economic loss due to the COVID-19 pandemic, relatives or acquaintances die from COVID-19, direct contact with COVID-19 patient(s), and fear of COVID-19 infection were associated with suicide risk. The COVID-19 pandemic imposes significant psychological consequences on people, thus, concerned authorities should pay attention to people's mental health and focus on suicide prevention and awareness during and after the COVID-19 pandemic.The COVID-19 pandemic imposes significant psychological consequences on people, thus, concerned authorities should pay attention to people's mental health and focus on suicide prevention and awareness during and after the COVID-19 pandemic. To test the hypotheses that blue light accelerates whitening through either (1) direct photobleaching or (2) photon-assisted oxidation using sequential longitudinal bleaching. Thirty extracted human tooth samples having natural life accumulated color were divided over five groups A. 9h light + 10h 6% H O gel + 6h light & 6% H O combined; B. 9h 6% H O gel + 10h light + 6h light & 6% H O combined; C. 11 h light & 6% H O combined; D. 8.45h 25 %H O gel + 10h of light only + 6h light & 25% H O combined E. 10.45 h light & 25 %H O combined. Blue light (456nm) was used at 190 mW/cm . Color change (ΔE) was measured over time, and reported after 48h color stabilization. Groups A, B and D reached saturation in the first phase (at 9h) at a ΔE of 4.3 ± 0.7, 4.9 ± 1.3 and 10.9 ± 2.2, respectively. Groups C and E achieved in the same time a significantly higher ΔE of 14.2 ± 1.7 and 15.6 ± 1.9, respectively. Subsequently adding the opposite single modality to groups A, B and D for 10h did reach an end stage at 8.

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