Evaluate the dentinogenesis in the offspring of rats submitted to gestational protein restriction (GPR). The offspring were evaluated at the 21st day of gestation (21dG). Assessments were made of morphological parameters and the RANKL/OPG system - bone tissue maturation markers - in the upper incisor tooth germ. Pregnant 10-week-old female Wistar rats were divided into normal protein (NP, 17% casein, n=5) and low protein (LP, 6% casein, n=5) diet groups. At 21dG, the offspring maxillae were collected for histomorphometric and immunohistochemical analyses. The LP group showed decreased thickness of the dentin and odontoblast cell layers on the tooth germ. GPR led to decreased OPG expression and increased RANKL expression in the incisor germ. The results suggested that gestational protein restriction altered odontoblast RANKL/OPG expression and decreased dentin matrix deposition and thickness in tooth development.The results suggested that gestational protein restriction altered odontoblast RANKL/OPG expression and decreased dentin matrix deposition and thickness in tooth development. Rapid maxillary expansion (RME) is the most frequent orthopedic procedure in cleft subjects. However, little is known about its effects on the mandible. The aim of this study was to investigate the spontaneous response of the mandibular teeth following RME. This prospective cohort study was carried out with a sample of thirty participants with unilateral cleft lip and palate (UCLP), 8-15 years old, who had transverse maxillary deficiency. Two participants were excluded. They were allocated into three groups G1 (n=10), G2 (n=10), and G3 (n=8). G1 was treated with a Fan-type expander; G2 with an iMini expander; and G3 with a Hyrax expander. Measurements were performed in Cone Beam CT scans obtained before treatment (T1) and 3 months post-expansion (T2). The primary outcomes were buccolingual inclination of mandibular first molars and canines, and intercanine and intermolar width at different levels. Dental changes were significant (P<0.05) for intercanine width, increasing in G1 and G2, and for intermolar width, increasing in G2 and G3. There were no significant differences among groups (P>0.05). RME in UCLP subjects performed with these expanders may lead to significant spontaneous changes in both anterior and posterior region of the mandible.RME in UCLP subjects performed with these expanders may lead to significant spontaneous changes in both anterior and posterior region of the mandible. To present a comprehensive review of current literature available on Corona virus disease and dentistry, modifications required in dental and laboratory settings; and recommended disinfection protocols in current scenario. Special emphasis has been given to discuss guidelines for handling different prosthodontic procedures and implications of this pandemic on prosthodontic practice, education and research. Relevant literature pertaining to COVID-19 and dentistry was scrutinized on electronic search engines including PubMed, EMBASE and Cochrane. Guidelines given by various organizations, institutions, national and international regulatory bodies and Indian Prosthodontic Society were also consulted to gather information pertaining to the objectives of our review. and observations A total of 160 articles including cross-sectional studies, in vitro study, narrative reviews, letters to the editor and opinions were found to be relevant in accordance with our search strategy. Documented literature revealed thacols to combat this unprecedented situation.Emergency managers (EMs) and Emergency Social Services Directors (ESSDs) are essential service providers who fulfill critical roles in disaster risk reduction. Despite being positioned throughout all levels of government, and in the private sector, EMs and ESSDs fulfill roles which occur largely behind the scenes. read more The purpose of this phenomenological study was to explore the roles of EMs and ESSDs from different regions across Canada. Specifically, we wanted to understand their perceptions of barriers, vulnerabilities and capabilities within the context of their roles. EMs (n = 15) and ESSDs (n = 6) from six Canadian provinces participated in semi-structured telephone interviews. Through content analysis, five themes and one model were generated from the data 1) Emergency management is not synonymous with first response, 2) Unrealistic expectations for a "side-of-desk" role, 3) Minding the gap between academia and practice with a 'whole-society' approach, 4) Personal preparedness tends to be weak, 5) Behind the scenes roles can have mental health implications. We present a model, based on these themes, which makes explicit the occupational risks that EMs and ESSDs may encounter in carrying out the skills, tasks, and roles of their jobs. Identification of occupational risks is a first step towards reducing vulnerabilities and supporting capability. This is particularly relevant in our current society as increased demands placed on these professionals coincides with the increasing frequency and severity of natural disasters due to climate change and the emergence of the world wide COVID-19 pandemic.von Willebrand factor (VWF) is exclusively expressed in endothelial cells (ECs) and megakaryocytes, which plays a crucial role in the initiation of arterial thrombosis. Recent studies have shown that VWF is also expressed in osteosarcoma (OS) cells and participates in adhesion of cancer cells to platelets, thus promoting metastasis of OS cells. However, it is unclear how OS cell-derived VWF-platelet interaction contributes to the metastasis of OS. We hypothesized that the interaction is mediated by the binding between VWF A1 and GPIbα of platelets, a molecular mechanism similar to that of thrombosis. The increased expression of VWF in SAOS2 cells may contribute to the enhancement of platelet adhesion through the VWF-GPIb pathway, which could promote the migration and invasion capacities of SAOS2 cells in vitro. Antibodies that block the pathway could significantly inhibit the platelet-induced metastasis of OS cells. Our results suggest a theoretical basis for the development of new anti-OS metastasis drugs, and further enrich the mechanism of OS metastasis.

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